45120-30-7

Basic information

• Product Name: L-Glutamic acid α-tert·butyl ester
• Synonyms: L-Glutamic acid α-tert·butyl ester;L-GLUTAMIC ACID ALPHA-TERTBUTYL ESTER;1-TERT-BUTYL L-GLUTAMATE,98.0+%(T);L-Glutamic Acid 1-tert-Butyl Ester;L-Glutamicacida-tertutylester;L-Glutamic acid 1-(1,1-dimethylethyl) ester;(S)-4-amino-5-tert-butoxy-5-oxopentanoic acid;α-tert-Butyl L-GlutaMate
• CAS NO: 45120-30-7
• Molecular Formula: C₉H₁₇NO₄
• Molecular Weight: 203.11
• Product Categories: Amino Acid tert-Butyl Esters;Amino Acids;Amino Acids (C-Protected);Biochemistry
• Mol File: 45120-30-7.mol
• Article Data: 2

Chemical Properties

• Melting Point: 140 °C
• Boiling Point: 326.8 °C at 760 mmHg
• Flash Point: 151.5 °C
• Appearance: White/Powder
• Density: 1.133 g/cm³
• Refractive Index: 14 ° (C=1, H2O)
• Storage Temp.: Store at 0°C
• Solubility: DMSO (Slightly), Methanol (Slightly), Water (Sparingly, Sonicated)
• PKA: 4.22±0.10(Predicted)
• CAS DataBase Reference: L-Glutamic acid α-tert·butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Glutamic acid α-tert·butyl ester(45120-30-7)
• EPA Substance Registry System: L-Glutamic acid α-tert·butyl ester(45120-30-7)

Safety Data

• Hazardous Substances Data: 45120-30-7(Hazardous Substances Data)

Usage

Description

L-Glutamic acid α-tert-butyl ester is an ester derivative of L-glutamic acid, a naturally occurring non-essential amino acid. It is a white solid and is widely utilized in the synthesis of enantiopure isotopomers of amino acids, which are crucial for various applications in the pharmaceutical and chemical industries.

Uses

Used in Pharmaceutical Industry:
L-Glutamic acid α-tert-butyl ester is used as a synthetic intermediate for the production of enantiopure isotopomers of amino acids. These isotopomers are essential in the development of novel drugs and therapeutic agents, as they can provide valuable insights into the structure-activity relationships of biologically active molecules.
Used in Chemical Industry:
In the chemical industry, L-Glutamic acid α-tert-butyl ester serves as a key building block for the synthesis of various chiral compounds and complex organic molecules. Its unique structural features make it a valuable asset in the development of new materials and catalysts with specific properties and applications.
Used in Research and Development:
L-Glutamic acid α-tert-butyl ester is also employed in research and development settings, where it is used to study the properties and reactivity of amino acid derivatives. This knowledge can be applied to the design and synthesis of new molecules with potential applications in various fields, including medicine, agriculture, and materials science.

Upstream product

• 617-65-2 Glutamic acid 
• 32677-01-3 L-glutamic acid di-tert-butyl ester hydrochloride 
• 16874-06-9 di-tert-butyl L-glutamate 

Downstream Products

• 84793-07-7 Fmoc-Glu-OtBu 
• 511544-85-7 α-tert-butyl N-[4-(N-benzyloxycarbonyl-N-methyl)aminobenzoyl]-L-glutamate 
• 79640-70-3 (S)-5-(tert-butoxy)-4-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)-5-oxopentanoic acid 
• 536721-25-2 L-glutamic acid, N-(1-oxohexadecyl)-, 1-(1,1-dimethylethyl) ester 
• 875667-99-5 di-tert-butyl N-{α-tert-butyl-N-[4-(N-benzyloxycarbonyl-N-methyl)aminobenzoyl]-L-glutamyl-γ}-L-glutamate 
• 875668-02-3 bis(pivaloyloxymethyl) N-{α-pivaloyloxymethyl-N-[4-(N-methyl)aminobenzoyl]-L-glutamyl-γ}-L-glutamate 
• 875668-01-2 bis(pivaloyloxymethyl) N-{α-pivaloyloxymethyl-N-[4-(N-benzyloxycarbonyl-N-methyl)aminobenzoyl]-L-glutamyl-γ}-L-glutamate 
• 685544-54-1 (S)-5-[2-(4-cyanophenyl)-1-oxo-2,8-diazaspiro[4.5]dec-8-yl]-2-(3,5-dimethylisoxazole-4-sulfonylamino)-5-oxopentanoic acid tert-butyl ester 
• 181040-47-1 N^α-[[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-(α-tert-butoxy)glutamoyl]-N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]glycinamide 
• 511544-99-3 N^α-[[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-(α-tert-butoxy)glutamoyl]-N-[1,1-bis(hydroxymethyl)-2-[(1-oxohexadecyl)oxy]ethyl]glycinamide 
• 181040-49-3 N^α-[[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-(α-tert-butoxy)glutamoyl]-N-[1-hydroxymethyl-2-[(1-oxohexadecyl)oxy]-1-[(1-oxohexadecyl)oxymethyl]ethyl]glycinamide 

Relevant articles and documents

Hydrolysis of amino acid diesters

The present invention provides a method for preparing an amino acid monoester from an amino acid diester without the use of an enzyme. Particularly, the method involves hydrolysis of an amino acid diester in the presence of a non-enzyme additive and under reaction conditions that affect selective hydrolysis of the α-ester group. The reaction conditions comprise a specific pH, temperature, and vapor pressure.