79640-70-3Relevant articles and documents
Methotrexate prodrugs sensitive to reactive oxygen species for the improved treatment of rheumatoid arthritis
Andersen, Nikolaj S.,Peiró Cadahía, Jorge,Previtali, Viola,Bondebjerg, Jon,Hansen, Christian A.,Hansen, Anders E.,Andresen, Thomas L.,Clausen, Mads H.
, p. 738 - 746 (2018/07/29)
Methotrexate (MTX) is the standard of care in the treatment of rheumatoid arthritis (RA), a common autoimmune disease that is characterized by chronic inflammation in the synovial membrane of joints. Unfortunately, MTX suffers from high discontinuation ra
PRODRUGS ACTIVATED BY REACTIVE OXYGEN SPECIES FOR USE IN THE TREATMENT OF INFLAMMATORY DISEASES AND CANCER
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Page/Page column 16-17, (2018/03/25)
Prodrugs activated predominantly or exclusively in inflammatory tissue, more particularly prodrugs of methotrexate and derivatives thereof, which are selectively activated by Reactive Oxygen Species (ROS) in inflammatory tissues associated with cancer and inflammatory diseases, as well as method for preparing said prodrugs.
Multifunctional small molecules
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Page/Page column 48, (2016/08/29)
The present invention relates to dendrimer synthesis. Specifically, the present invention relates to dendrimer compositions (e.g., scaffolds) capable of copper-free click conjugation for use in the synthesis of functionalized dendrimers, and methods of us