181040-47-1Relevant articles and documents
The use of Tris-lipidation to modify drug cytotoxicity in multidrug resistant cells expressing P-glycoprotein or MRP1
Davey, Ross A.,Davey, Mary W.,Cullen, Karen V.,Wells, Xanthe E.,Francis, Craig L.,Williams, Hua-Ming,Yang, Qi,Moghaddam, Minoo J.,Widmer, Fred,Whittaker, Robert G.
, p. 1280 - 1286 (2002)
1. Increasing the lipophilicity is a strategy often used to improve a compound's cellular uptake and retention but this may also convert it into a substrate for an ATP-dependent transporter such as P-glycoprotein or the multidrug resistance-associated pro