89035-33-6

Basic information

• Product Name: 5(4H)-Oxazolone, 4-[(5-bromo-2-thienyl)methylene]-2-phenyl-, (E)-
• CAS NO: 89035-33-6
• Molecular Formula: C14H8BrNO2S
• Molecular Weight: 334.193
• Mol File: 89035-33-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5(4H)-Oxazolone, 4-[(5-bromo-2-thienyl)methylene]-2-phenyl-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 5(4H)-Oxazolone, 4-[(5-bromo-2-thienyl)methylene]-2-phenyl-, (E)-(89035-33-6)
• EPA Substance Registry System: 5(4H)-Oxazolone, 4-[(5-bromo-2-thienyl)methylene]-2-phenyl-, (E)-(89035-33-6)

Safety Data

• Hazardous Substances Data: 89035-33-6(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 
• 1199-01-5 2-phenylazlactone 
• 495-69-2 Hippuric Acid 
• 89035-33-6 4-[1-(5-Bromo-thiophen-2-yl)-meth-(Z)-ylidene]-2-phenyl-4H-oxazol-5-one 

Downstream Products

• 88991-28-0 (E)-2-Benzoylamino-3-(5-bromo-thiophen-2-yl)-acrylic acid 
• 88991-51-9 4-(5-bromo-[2]thienylmethylene)-2-phenyl-4H-oxazol-5-one 
• 88991-27-9 (Z)-2-Benzoylamino-3-(5-bromo-thiophen-2-yl)-acrylic acid 
• 88991-42-8 (E)-2-Benzoylamino-3-(5-bromo-thiophen-2-yl)-acrylic acid methyl ester 
• 88991-41-7 (Z)-2-Benzoylamino-3-(5-bromo-thiophen-2-yl)-acrylic acid methyl ester 

Relevant articles and documents

Novel affinity ligands for chromatography using combinatorial chemistry

Spatially addressable combinatorial libraries were synthesized by solution phase chemistry and screened for binding to human serum albumin. Members of arylidene diamide libraries were among the best hits found, having submicromolar binding affinities. The results were analyzed by the frequency with which particular substituents appeared among the most potent compounds. After immobilization of the ligands either through the oxazolone or the amine substituent, characterization by surface plasmon resonance showed that ibuprofen affected the binding kinetics, but phenylbutazone did not. It is therefore likely that these compounds bind to Site 2 in sub domain IIIA of human serum albumin (HSA).