890707-28-5 Usage
Description
Bardoxolone is a synthetic oleanane triterpenoid with multifunctional activities in the control of cellular growth and differentiation. It is capable of activating the transcription factor peroxisome proliferator activator receptor-γ (PPARγ) and exhibits apoptotic effects in malignant cells independently of PPARγ. Bardoxolone is an off-white powder and has been developed as a potential drug for the improvement of hyperglycemia, proteinuria, glomerulus structure, and serum creatine, which may be beneficial in treating diabetic kidney diseases, cancer, and thromboembolic events.
Uses
Used in Pharmaceutical Industry:
Bardoxolone is used as a potential drug for the treatment of diabetic kidney diseases, cancer, and thromboembolic events. Its multifunctional activities in controlling cellular growth and differentiation, along with its ability to activate PPARγ and induce apoptosis in malignant cells, make it a promising candidate for these applications.
Used in Diabetes Management:
Bardoxolone is used as an agent for improving hyperglycemia, proteinuria, glomerulus structure, and serum creatine levels in patients with diabetic kidney diseases. Its potential to regulate these parameters may contribute to better management and treatment outcomes for diabetes-related complications.
Used in Cancer Therapy:
Bardoxolone is used as an anticancer agent, targeting malignant cells and inducing apoptosis independently of PPARγ. Its multifunctional activities in controlling cellular growth and differentiation make it a promising candidate for cancer treatment, potentially offering a new approach to managing this disease.
Used in Thromboembolic Event Prevention:
Bardoxolone is used as a preventive agent for thromboembolic events. Its potential to improve serum creatine levels and other related parameters may contribute to reducing the risk of thromboembolic complications in at-risk patients.
Check Digit Verification of cas no
The CAS Registry Mumber 890707-28-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,9,0,7,0 and 7 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 890707-28:
(8*8)+(7*9)+(6*0)+(5*7)+(4*0)+(3*7)+(2*2)+(1*8)=195
195 % 10 = 5
So 890707-28-5 is a valid CAS Registry Number.
890707-28-5Relevant articles and documents
A PROCESS FOR THE SYNTHESIS OF ANTHRANILIC ACID/AMIDE COMPOUNDS AND INTERMEDIATES THEREOF
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, (2022/04/03)
The present invention disclosed a process for the synthesis of compound of formula (Z) or a salt thereof, wherein, R, R1, R2, R3 and R10 are as defined in the detailed description. The process further comprises the synthesis of an anthranilic diamide compound of formula (I).
AN EFFICIENT NEW PROCESS FOR SYNTHESIS OF 2-AMINO-5-CHLORO-N-,3-DIMETHYLBENZAMIDE
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, (2021/05/07)
Described herein are novel methods of synthesizing 2-amino-5-chloro-N,3- dimethylbenzamide. Compounds prepared by the methods disclosed herein are useful for preparation of certain anthranilamide compounds that are of interest as insecticides, such as, for example, the insecticides chlorantraniliprole and cyantraniliprole.
PROCESS FOR THE PREPARATION OF CHLORANTRANILIPROLE
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, (2021/02/26)
The present invention relates to two novel, efficient and one-pot methods for synthesizing chlorantraniliprole. In the first scheme, Chlorantraniliprole is prepared by a novel telescopic process starting from 3-Bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid a key raw material-A (Key RM-A). In the second scheme, starting from Key RM-A, the process steps use of a novel variant of anthranilic acid (Methyl 2-amino-5-chloro-3-methylbenzoate), to get Chlorantraniliprole. Furthermore, the present invention also relates to the synthesis of key starting material for the synthesizing chlorantraniliprole in-situ. All the in-situ steps of the disclosed synthesis methods obtain good yield, without using any expensive reagent or base or harsh reaction conditions, which makes the process simple, environment friendly and more cost effective. With this process the production cost of chlorantraniliprole and its intermediates is substantially reduced; fewer by-products are formed during its synthesis and since it's a one-pot reaction, isolation and purification are easy to achieve.