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Win-Win chemical Co.Ltd

Stock products, own laboratory Description Product number PC00441 English Name 2-Amino-5-chloro-N,3-dimethylbenzamide CAS Number 890707-28-5

2-Amino-5-chloro-N,3-dimethylbenzamide cas no. 890707-28-5 98%

Cas:890707-28-5

Min.Order:1 Metric Ton

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Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

Identification: Product Name: Pyrazolic acid Chemical Name: 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid; Synonyms: K Acid ; 3-bromo-1-(3-chloro-2-pyridinyl)-1H-Pyrazole-5-carboxylic acid CAS No.: 500011-86-9 Molecular F

factory supply 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid

Cas:890707-28-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hebei Qianen Pharma Tech Co.,Ltd.

High purity, content greater than 99% Pharmaceutical level quality control Factory direct Ready delivery from stock Application:Pharmaceutical intermediates

Bardoxolone

Cas:890707-28-5

Min.Order:1 Metric Ton

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Type:Trading Company

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Henan Allgreen Chemical Co.,Ltd

890707-28-5 Basic information Product Name: 890707-28-5 Synonyms: 890707-28-5;2-Amino-5-chloro-N,3-dimethylbenzamide CAS: 890707-28-5

C9H11ClN2O

Cas:890707-28-5

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2-Amino-5-Chloro-N,3-Dimethylbenzamide

Cas:890707-28-5

Min.Order:1

Negotiable

Type:Other

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

2-AMINO-5-CHLORO-N,3-DIMETHYLBENZAMIDE

Cas:890707-28-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 890707-28-5 with best quality

Cas:890707-28-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2-Amino-3-methyl-N-methylbenzamide 890707-28-5

Cas:890707-28-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

Bardoxolone Basic information Product Name: Bardoxolone Synonyms: 2-Amino-5-chloro-N,3-dimethylbenzamide;2-Amino-5-chloro-N,3-dimethylbenzamide 98%;Benzamide, 2-amino-5-chloro-N,3-dimethyl- CAS: 890707-28-5 MF: C9H11ClN2O MW: 198.65 EI

Bardoxolone

Cas:890707-28-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

Bardoxolone CAS:890707-28-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate

Bardoxolone CAS:890707-28-5

Cas:890707-28-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hebei Mojin Biotechnology Co.,Ltd

Product quality: Our company have high quality product , and also the product we have good manufacture . First of all, this product is of fine quality. Every finish should be checked by quality inspection system.And every one should be also tried

2-Amino-5-chloro-N,3-dimethylbenzamide cas no. 890707-28-5 98%

Cas:890707-28-5

Min.Order:1 Kilogram

FOB Price: $20.0 / 30.0

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2-Amino-3-methyl-N-methylbenzamide

Cas:890707-28-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2-Amino-5-Chloro-N,3-Dimethylbenzamide

Cas:890707-28-5

Min.Order:0

Negotiable

Type:Manufacturers

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Hot sale !890707-28-5 99% high purity in stock

Cas:890707-28-5

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

2-Amino-5-chloro-N,3-dimethylhenzamide

Cas:890707-28-5

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hefei Zhaobo Technology Co., Ltd.

Our Advantages Production: Advanced chemical equipment with years of experience.Staffs for producing various extract products. Quality Control:A complete set of Testing Professional and Analysis Equipment ensures the Quality Requirements and Speci

Bardoxolone CAS 890707-28-5

Cas:890707-28-5

Min.Order:1 Kilogram

FOB Price: $150.0 / 180.0

Type:Trading Company

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

2-Amino-5-chloro-N,3-dimethylbenzamide

Cas:890707-28-5

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

Bardoxolone

Cas:890707-28-5

Min.Order:1 Kilogram

FOB Price: $50.0 / 100.0

Type:Trading Company

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Hot sale !890707-28-5 99% high purity in stock

Cas:890707-28-5

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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Siwei Development Group Ltd.

Product name: 2-Amino-5-Chloro-N,3-Dimethylbenzamide CAS No.: 890707-28-5 Molecule Formula:C9H11ClN2O Molecule Weight:198.65 Purity: 98.5% Package: 25kg/drum Description:White or off-white powder Manufacture Standards:Enterprise Stand

Lower Price 2-Amino-5-Chloro-N,3-Dimethylbenzamide

Cas:890707-28-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Fandachem Co.,Ltd

Hangzhou Fanda Chemical Co.,Ltd (FandaChem) , a China-based chemical company, specialize in exporting 2-Amino-5-chloro-N,3-dimethylbenzamide CAS:890707-28-5, Please contact us by email freely. We are leading exporter in China. If you

2-Amino-5-chloro-N,3-dimethylbenzamide CAS:890707-28-5 from fandachem

Cas:890707-28-5

Min.Order:0 Metric Ton

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Type:Other

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Wuhan BJM Pharm Inc.

Category Pharmaceutical Raw Materials, Fine Chemicals, Bulk drug Standard Medical standard Shelf life 2 years Storage should be stored in a well-closed container at low temperature, keep away from mo

2-Amino-5-Chloro-N,3-Dimethylbenzamide high quality supplier

Cas:890707-28-5

Min.Order:1 Kilogram

FOB Price: $30.0 / 65.0

Type:Lab/Research institutions

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Hot sale !890707-28-5 99% high purity in stock

Cas:890707-28-5

Min.Order:1 Gram

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Type:Lab/Research institutions

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Hot sale !890707-28-5 99% high purity in stock

Cas:890707-28-5

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

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Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis:

2-Amino-5-chloro-N,3-dimethylbenzamide

Cas:890707-28-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

2-Amino-5-chloro-N,3-dimethylbenzamide

Cas:890707-28-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:as per your request Application:Used as Pharmaceutical Intermediates,ect. Transportation:as per your request

2-Amino-5-chloro-N,3-dimethylbenzamide

Cas:890707-28-5

Min.Order:10 Gram

Negotiable

Type:Trading Company

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Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Hot sale !890707-28-5 99% high purity in stock

Cas:890707-28-5

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

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GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

2-Amino-5-chloro-N,3-dimethylbenzamide

Cas:890707-28-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

2-Amino-5-Chloro-N,3-Dimethylbenzamide

Cas:890707-28-5

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

2-amino-3-methyl-5-chlorobenzoic acid methyl ester
79101-83-0

2-amino-3-methyl-5-chlorobenzoic acid methyl ester

methylamine
74-89-5

methylamine

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

Conditions
ConditionsYield
In methanol at 65 - 68℃; for 5h; Temperature;98%
In methanol at 45℃; for 6h;97.2%
In ethylene glycol; acetonitrile at 0 - 70℃; for 17.5 - 23h; Product distribution / selectivity;84.8%
isopropyl 2-amino-5-chloro-3-methylbenzoate

isopropyl 2-amino-5-chloro-3-methylbenzoate

methylamine
74-89-5

methylamine

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

Conditions
ConditionsYield
In isopropyl alcohol at 60℃; for 7h;96.8%
2-amino-5-chloro-3-methylbenzoic acid ethyl ester

2-amino-5-chloro-3-methylbenzoic acid ethyl ester

methylamine
74-89-5

methylamine

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

Conditions
ConditionsYield
In methanol at 50℃; for 6h;95.4%
6-chloro-8-methyl-1H-benzo[d][1,3]oxazine-2,4-dione
120374-68-7

6-chloro-8-methyl-1H-benzo[d][1,3]oxazine-2,4-dione

methylamine
74-89-5

methylamine

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

Conditions
ConditionsYield
With acetic acid In ethyl acetate at 35 - 45℃; for 0.333333h;95%
With acetic acid In ethyl acetate at 22 - 52℃; for 0.333333 - 2.75h; Product distribution / selectivity;93%
With acetic acid In water; acetonitrile at 25 - 30℃; for 2.5h; Product distribution / selectivity;87%
6-chloro-8-methyl-1H-benzo[d][1,3]oxazine-2,4-dione
120374-68-7

6-chloro-8-methyl-1H-benzo[d][1,3]oxazine-2,4-dione

methylamine hydrochloride
593-51-1

methylamine hydrochloride

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

Conditions
ConditionsYield
With potassium hydrogencarbonate In acetonitrile at 25 - 30℃; for 3h; Solvent; Reagent/catalyst; Temperature;93.6%
Stage #1: methylamine hydrochloride With triethylamine In dichloromethane at 20℃; for 2h;
Stage #2: 6-chloro-8-methyl-1H-benzo[d][1,3]oxazine-2,4-dione With acetic acid In dichloromethane; ethyl acetate Reflux;
With potassium carbonate In ethanol at 25 - 80℃; for 5.5h; Reagent/catalyst; Temperature;
2-amino-5-chloro-3-methylbenzoic acid
20776-67-4

2-amino-5-chloro-3-methylbenzoic acid

methylamine
74-89-5

methylamine

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

Conditions
ConditionsYield
Stage #1: 2-amino-5-chloro-3-methylbenzoic acid With benzotriazol-1-ol; diisopropyl-carbodiimide In dichloromethane at 20℃; for 2h;
Stage #2: methylamine In dichloromethane at 0℃; for 2h; Temperature;
92.6%
Stage #1: 2-amino-5-chloro-3-methylbenzoic acid With thionyl chloride for 3h; Reflux;
Stage #2: methylamine In tetrahydrofuran; water at 20℃; Cooling with ice;
59.3%
Stage #1: 2-amino-5-chloro-3-methylbenzoic acid With thionyl chloride for 3h; Reflux;
Stage #2: methylamine In tetrahydrofuran; water at 20℃; for 12h; Cooling with ice;
59.3%
6-chloro-8-methyl-1H-benzo[d][1,3]oxazine-2,4-dione
120374-68-7

6-chloro-8-methyl-1H-benzo[d][1,3]oxazine-2,4-dione

methylamine
74-89-5

methylamine

A

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

B

6-chloro-3,8-dimethyl-2,4(1H,3H)-quinazolinedione

6-chloro-3,8-dimethyl-2,4(1H,3H)-quinazolinedione

C

2-amino-5-chloro-3-methylbenzoic acid
20776-67-4

2-amino-5-chloro-3-methylbenzoic acid

Conditions
ConditionsYield
With water; acetic acid In ethyl acetate at 48 - 52℃; for 1h; Product distribution / selectivity;A 87.3%
B 3.4%
C 1.7%
N-methyl-3-methyl-2-aminobenzamide
870997-57-2

N-methyl-3-methyl-2-aminobenzamide

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

Conditions
ConditionsYield
With hydrogenchloride; dihydrogen peroxide; acetic acid at 5 - 20℃;85%
Stage #1: N-methyl-3-methyl-2-aminobenzamide With hydrogenchloride In N,N-dimethyl-formamide at 10 - 30℃;
Stage #2: With sodium sulfite In water; N,N-dimethyl-formamide at 30 - 35℃; for 3.25h;
Stage #3: With sodium hydroxide; sodium sulfite In water; N,N-dimethyl-formamide at 10℃; for 0.25h; pH=2.2; Product distribution / selectivity;
72.7%
With N-chloro-succinimide In acetonitrile for 1h; Reflux;
With sulfuryl dichloride In dichloromethane at 0 - 30℃;
With thionyl chloride In acetonitrile at 40 - 50℃;
carbon monoxide
201230-82-2

carbon monoxide

2-bromo-4-chloro-6-methylphenylamine
146948-68-7

2-bromo-4-chloro-6-methylphenylamine

methylamine
74-89-5

methylamine

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

Conditions
ConditionsYield
palladium diacetate; 1,4-di(diphenylphosphino)-butane In ethylene glycol at 25 - 110℃; under 2842.59 Torr; Inert atmosphere; Sealed tube;70%
2-amino-5-chloro-3-methylbenzoyl chloride

2-amino-5-chloro-3-methylbenzoyl chloride

methylamine
74-89-5

methylamine

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

Conditions
ConditionsYield
In dichloromethane
In dichloromethane
2-amino-5-chloro-3-methylbenzoic acid
20776-67-4

2-amino-5-chloro-3-methylbenzoic acid

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: thionyl chloride / Reflux
2: dichloromethane
View Scheme
Multi-step reaction with 2 steps
1: thionyl chloride / 3 h / Reflux
2: dichloromethane
View Scheme
Multi-step reaction with 2 steps
1.1: 1,4-dioxane / 2 h / 50 °C
2.1: triethylamine / dichloromethane / 2 h / 20 °C
2.2: Reflux
View Scheme
2-hydroxyethyl 2-amino-5-chloro-3-methylbenzoate
1391132-23-2

2-hydroxyethyl 2-amino-5-chloro-3-methylbenzoate

2-(dimethylamino)ethyl 2-amino-5-chloro-3-methylbenzoate
1391132-24-3

2-(dimethylamino)ethyl 2-amino-5-chloro-3-methylbenzoate

methylamine
74-89-5

methylamine

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

Conditions
ConditionsYield
at 110℃; under 3876.26 Torr; for 6.06667h; Product distribution / selectivity; Sealed tube; Inert atmosphere;
3-methylantranilic acid
4389-45-1

3-methylantranilic acid

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.67 h / 100 °C
2.1: thionyl chloride / 3 h / Reflux
2.2: 20 °C / Cooling with ice
View Scheme
Multi-step reaction with 2 steps
1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.67 h / 100 °C
2.1: thionyl chloride / 3 h / Reflux
2.2: 12 h / 20 °C / Cooling with ice
View Scheme
Multi-step reaction with 2 steps
1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / Cooling with ice
2: N-chloro-succinimide / acetonitrile / 1 h / Reflux
View Scheme
o-toluidine
95-53-4

o-toluidine

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium sulfate / water / 40 °C
1.2: Reflux
2.1: sulfuric acid / 0.33 h / 80 °C
3.1: dihydrogen peroxide; sodium hydroxide / water / 0 - 50 °C
4.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.67 h / 100 °C
5.1: thionyl chloride / 3 h / Reflux
5.2: 20 °C / Cooling with ice
View Scheme
Multi-step reaction with 5 steps
1.1: sodium sulfate / water / 40 °C
1.2: 0.17 h / Reflux
2.1: sulfuric acid / 60 - 80 °C
3.1: dihydrogen peroxide; sodium hydroxide / water / 0.5 h / 0 - 50 °C
3.2: pH 4
4.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.67 h / 100 °C
5.1: thionyl chloride / 3 h / Reflux
5.2: 12 h / 20 °C / Cooling with ice
View Scheme
Multi-step reaction with 5 steps
1.1: sodium sulfate; hydrogenchloride; hydroxylamine hydrochloride / water / 0.17 h / Reflux
2.1: sulfuric acid / 0.83 h / 70 - 80 °C
3.1: dihydrogen peroxide; sodium hydroxide / water / 0.5 h / 0 - 50 °C
4.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.67 h / 100 °C
5.1: thionyl chloride / 3 h / Reflux
5.2: 12 h / 20 °C / Cooling with ice
View Scheme
2-(hydroxyimino)-N-(2-methylphenyl)acetamide
1132-03-2

2-(hydroxyimino)-N-(2-methylphenyl)acetamide

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sulfuric acid / 0.33 h / 80 °C
2.1: dihydrogen peroxide; sodium hydroxide / water / 0 - 50 °C
3.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.67 h / 100 °C
4.1: thionyl chloride / 3 h / Reflux
4.2: 20 °C / Cooling with ice
View Scheme
Multi-step reaction with 4 steps
1.1: sulfuric acid / 60 - 80 °C
2.1: dihydrogen peroxide; sodium hydroxide / water / 0.5 h / 0 - 50 °C
2.2: pH 4
3.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.67 h / 100 °C
4.1: thionyl chloride / 3 h / Reflux
4.2: 12 h / 20 °C / Cooling with ice
View Scheme
Multi-step reaction with 4 steps
1.1: sulfuric acid / 0.83 h / 70 - 80 °C
2.1: dihydrogen peroxide; sodium hydroxide / water / 0.5 h / 0 - 50 °C
3.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.67 h / 100 °C
4.1: thionyl chloride / 3 h / Reflux
4.2: 12 h / 20 °C / Cooling with ice
View Scheme
Multi-step reaction with 3 steps
1.1: sulfuric acid / 1,2-dichloro-ethane / 12 h / 0 - 30 °C
2.1: acetic acid; dihydrogen peroxide / 0.25 h / 5 °C
2.2: 28.17 h / 5 - 20 °C
2.3: 3.75 h / 10 - 40 °C
3.1: acetic acid / ethyl acetate / 3.25 h / 0 - 25 °C / pH 9 - 10
View Scheme
Multi-step reaction with 3 steps
1.1: sulfuric acid / 1,2-dichloro-ethane / 12 h / 0 - 30 °C
2.1: acetic acid; dihydrogen peroxide / 0.25 h / 5 °C
2.2: 28.17 h / 5 - 20 °C
2.3: 3.75 h / 10 - 40 °C
3.1: potassium carbonate / ethanol / 5.5 h / 25 - 80 °C
View Scheme
7-methyl-1H-indole-2,3-dione
1127-59-9

7-methyl-1H-indole-2,3-dione

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: dihydrogen peroxide; sodium hydroxide / water / 0 - 50 °C
2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.67 h / 100 °C
3.1: thionyl chloride / 3 h / Reflux
3.2: 20 °C / Cooling with ice
View Scheme
Multi-step reaction with 3 steps
1.1: dihydrogen peroxide; sodium hydroxide / water / 0.5 h / 0 - 50 °C
1.2: pH 4
2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.67 h / 100 °C
3.1: thionyl chloride / 3 h / Reflux
3.2: 12 h / 20 °C / Cooling with ice
View Scheme
Multi-step reaction with 3 steps
1.1: dihydrogen peroxide; sodium hydroxide / water / 0.5 h / 0 - 50 °C
2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.67 h / 100 °C
3.1: thionyl chloride / 3 h / Reflux
3.2: 12 h / 20 °C / Cooling with ice
View Scheme
Multi-step reaction with 2 steps
1.1: acetic acid; dihydrogen peroxide / 0.25 h / 5 °C
1.2: 28.17 h / 5 - 20 °C
1.3: 3.75 h / 10 - 40 °C
2.1: acetic acid / ethyl acetate / 3.25 h / 0 - 25 °C / pH 9 - 10
View Scheme
Multi-step reaction with 3 steps
1: sulfuryl dichloride; acetic acid / 120 - 125 °C
2: sulfuric acid; acetic acid; dihydrogen peroxide / 60 - 65 °C
3: ethyl acetate / 20 °C
View Scheme
benzoic acid
65-85-0

benzoic acid

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: acetic acid; chlorine / 3 h / 30 - 40 °C / Inert atmosphere
2.1: 0.08 h
2.2: Grignard reagent / 1 h
3.1: sulfuric acid; nitric acid / 1 h / 0 - 40 °C
4.1: zinc; sodium hydroxide / 2 h / 70 °C
5.1: diisopropyl-carbodiimide; benzotriazol-1-ol / dichloromethane / 2 h / 20 °C
5.2: 2 h / 0 °C
View Scheme
3,5-dichlorobenzoic acid
51-36-5

3,5-dichlorobenzoic acid

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 0.08 h
1.2: Grignard reagent / 1 h
2.1: sulfuric acid; nitric acid / 1 h / 0 - 40 °C
3.1: zinc; sodium hydroxide / 2 h / 70 °C
4.1: diisopropyl-carbodiimide; benzotriazol-1-ol / dichloromethane / 2 h / 20 °C
4.2: 2 h / 0 °C
View Scheme
3-Chloro-5-Methylbenzoic Acid
56961-33-2

3-Chloro-5-Methylbenzoic Acid

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sulfuric acid; nitric acid / 1 h / 0 - 40 °C
2.1: zinc; sodium hydroxide / 2 h / 70 °C
3.1: diisopropyl-carbodiimide; benzotriazol-1-ol / dichloromethane / 2 h / 20 °C
3.2: 2 h / 0 °C
View Scheme
toluene
108-88-3

toluene

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: oxygen; cobalt(II) aceylacetonate; N-hydroxyphthalimide / dichloromethane / 1 h / 30 °C / 22502.3 Torr / Sealed tube
2.1: acetic acid; chlorine / 3 h / 30 - 40 °C / Inert atmosphere
3.1: 0.08 h
3.2: Grignard reagent / 1 h
4.1: sulfuric acid; nitric acid / 1 h / 0 - 40 °C
5.1: zinc; sodium hydroxide / 2 h / 70 °C
6.1: diisopropyl-carbodiimide; benzotriazol-1-ol / dichloromethane / 2 h / 20 °C
6.2: 2 h / 0 °C
View Scheme
2-methyl-4,6-dichloroaniline
30273-00-8

2-methyl-4,6-dichloroaniline

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: copper bromide / N,N-dimethyl-formamide / 18 h / 90 - 95 °C
2: sodium hydroxide / 10 h / 70 - 75 °C
3: sulfuric acid / 16 h / Reflux
4: methanol / 5 h / 65 - 68 °C
View Scheme
2-amino-5-chloro-3-methylbenzonitrile
939990-03-1

2-amino-5-chloro-3-methylbenzonitrile

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide / 10 h / 70 - 75 °C
2: sulfuric acid / 16 h / Reflux
3: methanol / 5 h / 65 - 68 °C
View Scheme
3-methyl-2-nitrobenzoic acid
5437-38-7

3-methyl-2-nitrobenzoic acid

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: hydrogen / ethanol / 4 h / 50 °C / 1500.15 Torr
2: chlorine / 1,2-dichloro-ethane / 3 h / 50 °C
3: sulfuric acid / 6 h / 5 °C / Reflux
4: isopropyl alcohol / 7 h / 60 °C
View Scheme
Multi-step reaction with 4 steps
1: hydrogen / ethanol / 4 h / 50 °C / 1500.15 Torr
2: chlorine / 1,2-dichloro-ethane / 3 h / 50 °C
3: sulfuric acid / 6 h / 5 °C / Reflux
4: methanol / 6 h / 50 °C
View Scheme
Multi-step reaction with 4 steps
1: hydrogen / ethanol / 4 h / 50 °C / 1500.15 Torr
2: chlorine / 1,2-dichloro-ethane / 3 h / 50 °C
3: sulfuric acid / 8 h / 5 °C / Reflux
4: methanol / 6 h / 45 °C
View Scheme
Multi-step reaction with 3 steps
1.1: thionyl chloride / toluene / 90 - 100 °C
1.2: 0 - 10 °C
2.1: palladium 10% on activated carbon; hydrogen / methanol
3.1: acetic acid; hydrogenchloride; dihydrogen peroxide / 5 - 20 °C
View Scheme
Multi-step reaction with 4 steps
1: pyrographite; hydrazine hydrate; sodium hydroxide; iron(III) chloride hexahydrate / water / 70 °C
2: pyridine / acetonitrile / 4 h / 50 - 60 °C
3: acetic acid / water; acetonitrile / 1 h / Reflux
4: thionyl chloride / acetonitrile / 40 - 50 °C
View Scheme
m-Toluic acid
99-04-7

m-Toluic acid

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: nitric acid / -10 - -5 °C
2.1: thionyl chloride / toluene / 90 - 100 °C
2.2: 0 - 10 °C
3.1: palladium 10% on activated carbon; hydrogen / methanol
4.1: acetic acid; hydrogenchloride; dihydrogen peroxide / 5 - 20 °C
View Scheme
N,3-dimethyl-2-nitrobenzamide
600126-70-3

N,3-dimethyl-2-nitrobenzamide

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: palladium 10% on activated carbon; hydrogen / methanol
2: acetic acid; hydrogenchloride; dihydrogen peroxide / 5 - 20 °C
View Scheme
6-methylisatoic anhydride
66176-17-8

6-methylisatoic anhydride

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetic acid / water; acetonitrile / 1 h / Reflux
2: thionyl chloride / acetonitrile / 40 - 50 °C
View Scheme
5-chloro-7-methyl-1H-indole-2,3-dione
14389-06-1

5-chloro-7-methyl-1H-indole-2,3-dione

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sulfuric acid; acetic acid; dihydrogen peroxide / 60 - 65 °C
2: ethyl acetate / 20 °C
View Scheme
(E)-2-(hydroxyimino)-N-(o-tolyl)acetamide

(E)-2-(hydroxyimino)-N-(o-tolyl)acetamide

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sulfuric acid / 60 - 65 °C
2: sulfuryl dichloride; acetic acid; dihydrogen peroxide / 60 - 125 °C
3: ethyl acetate / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: sulfuric acid / 60 - 65 °C
2: sulfuryl dichloride; acetic acid / 120 - 125 °C
3: sulfuric acid; acetic acid; dihydrogen peroxide / 60 - 65 °C
4: ethyl acetate / 20 °C
View Scheme
3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid
500011-86-9

3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

rynaxypyr
500008-45-7

rynaxypyr

Conditions
ConditionsYield
With 3-Methylpyridine; methanesulfonyl chloride In propiononitrile at -5 - 20℃; for 4h; Product distribution / selectivity;97%
With 3-Methylpyridine; methanesulfonyl chloride In acetone at -5 - 5℃; for 3h; Product distribution / selectivity;96.4%
With pyridine; methanesulfonyl chloride In acetonitrile at -5 - 20℃; for 4h; Product distribution / selectivity;96.8%
2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

C9H6Br2ClN3O2

C9H6Br2ClN3O2

C18H15Br2Cl2N5O2

C18H15Br2Cl2N5O2

Conditions
ConditionsYield
With pyridine; methanesulfonyl chloride In acetonitrile at -5℃; for 2.16h;95.6%
2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

acetone
67-64-1

acetone

6-chloro-2,2,3,8-tetramethyl-2,3-dihydroquinazolin-4(1H)-one
1488427-93-5

6-chloro-2,2,3,8-tetramethyl-2,3-dihydroquinazolin-4(1H)-one

Conditions
ConditionsYield
With toluene-4-sulfonic acid for 1h; Reflux;95%
furfural
98-01-1

furfural

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

6-chloro-2-(furan-2-yl)-3,8-dimethyl-2,3-dihydroquinazolin-4(1H)-one
1542270-67-6

6-chloro-2-(furan-2-yl)-3,8-dimethyl-2,3-dihydroquinazolin-4(1H)-one

Conditions
ConditionsYield
With β-cyclodextrine-SO3H In water at 50℃; for 0.416667h; Green chemistry;94%
2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxaldehyde
1072138-63-6

3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxaldehyde

C18H14BrCl2N5O
1351217-99-6

C18H14BrCl2N5O

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene for 1h; Reflux;92%
2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carbonyl chloride
943982-60-3

3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carbonyl chloride

rynaxypyr
500008-45-7

rynaxypyr

Conditions
ConditionsYield
Stage #1: 2-amino-3-methyl-5-chlorobenzoyl-N-methylamine With 3-Methylpyridine In acetonitrile at 25 - 35℃;
Stage #2: 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carbonyl chloride In acetonitrile at 25 - 35℃; Solvent; Temperature;
91.1%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 12h; Cooling with ice;89.3%
Stage #1: 2-amino-3-methyl-5-chlorobenzoyl-N-methylamine; 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carbonyl chloride In acetonitrile at 20℃; for 1.16667h; Reflux;
Stage #2: With sodium hydrogencarbonate In acetonitrile Product distribution / selectivity;
2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

cyclohexanone
108-94-1

cyclohexanone

6'-chloro-3',8'-dimethyl-1'H-spiro[cyclohexane-1,2'-quinazolin]-4'(3'H)-one
1542270-66-5

6'-chloro-3',8'-dimethyl-1'H-spiro[cyclohexane-1,2'-quinazolin]-4'(3'H)-one

Conditions
ConditionsYield
With β-cyclodextrine-SO3H In water at 50℃; for 0.416667h; Green chemistry;90%
2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carbonyl chloride

3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carbonyl chloride

rynaxypyr
500008-45-7

rynaxypyr

Conditions
ConditionsYield
In acetonitrile at 20℃; for 3.16667h; Reflux;84%
2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

dicyanozinc
557-21-1

dicyanozinc

2-amino-3-methyl-5-cyanobenzoyl-N-methylamine

2-amino-3-methyl-5-cyanobenzoyl-N-methylamine

Conditions
ConditionsYield
With zinc; bis(tri-tert-butylphosphine)palladium(0) In 1,4-dioxane for 11h; Product distribution / selectivity; Heating / reflux;83%
2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

potassium cyanide
151-50-8

potassium cyanide

2-amino-3-methyl-5-cyanobenzoyl-N-methylamine

2-amino-3-methyl-5-cyanobenzoyl-N-methylamine

Conditions
ConditionsYield
chloro(1-naphthyl)bis(triphenylphosphine)nickel(II); chloro(2-naphthalenyl)bis(triphenylphosphine)nickel In ethanol; xylene at 45℃; Product distribution / selectivity;82.5%
With zinc; bis(tri-tert-butylphosphine)palladium(0); 18-crown-6 ether In 1,4-dioxane for 24h; Product distribution / selectivity; Heating / reflux;65%
2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

C9H6ClN3O
1450664-91-1

C9H6ClN3O

6-chloro-2-(3-chloro-1-(pyridin-2-yl)-1H-pyrazol-5-yl)-3-cyclopropyl-8-methyl-2,3-dihydroquinazolin-4(1H)-one
1450664-92-2

6-chloro-2-(3-chloro-1-(pyridin-2-yl)-1H-pyrazol-5-yl)-3-cyclopropyl-8-methyl-2,3-dihydroquinazolin-4(1H)-one

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene for 1h; Reflux;82%
2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

1-(3,5-dichloropyridin-2-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride

1-(3,5-dichloropyridin-2-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride

C19H13Cl3F3N5O2
1104384-03-3

C19H13Cl3F3N5O2

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 3h;81%
2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

1-(3,5-dichloropyridin-2-yl)-3-(prop-2-ynyloxy)-1H-pyrazole-5-carbonyl chloride
1104384-31-7

1-(3,5-dichloropyridin-2-yl)-3-(prop-2-ynyloxy)-1H-pyrazole-5-carbonyl chloride

C21H16Cl3N5O3
1104384-07-7

C21H16Cl3N5O3

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 3h;81%
2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

C8H3Cl3N4O

C8H3Cl3N4O

N-(2-(methylcarbamoyl)-4-chloro-6-methylphenyl)-3-chloro-1-(6-chloropyrazin-2-yl)-1H-pyrazole-5-carboxamide

N-(2-(methylcarbamoyl)-4-chloro-6-methylphenyl)-3-chloro-1-(6-chloropyrazin-2-yl)-1H-pyrazole-5-carboxamide

Conditions
ConditionsYield
With triethylamine In acetonitrile76%
2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

1-(6-chloropyrazin-2-yl)-3-bromo-1H-pyrazole-5-carbonyl chloride

1-(6-chloropyrazin-2-yl)-3-bromo-1H-pyrazole-5-carbonyl chloride

N-(2-(methylcarbamoyl)-4-chloro-6-methylphenyl)-3-bromo-1-(6-chloropyrazin-2-yl)-1H-pyrazole-5-carboxamide

N-(2-(methylcarbamoyl)-4-chloro-6-methylphenyl)-3-bromo-1-(6-chloropyrazin-2-yl)-1H-pyrazole-5-carboxamide

Conditions
ConditionsYield
With triethylamine In acetonitrile75%
2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

C12H7Cl2F2N3O2

C12H7Cl2F2N3O2

N5-(4-chloro-2-methyl-6-(methylcarbamoyl)phenyl)-1-(2-chloro-4,5-difluorophenyl)-N3-methyl-1H-pyrazole-3,5-dicarboxamide

N5-(4-chloro-2-methyl-6-(methylcarbamoyl)phenyl)-1-(2-chloro-4,5-difluorophenyl)-N3-methyl-1H-pyrazole-3,5-dicarboxamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 12h;75%
2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

C12H7Cl2F3N2O2

C12H7Cl2F3N2O2

N-(4-chloro-2-methyl-6-(methylcarbamoyl)phenyl)-1-(2-chloro-5-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

N-(4-chloro-2-methyl-6-(methylcarbamoyl)phenyl)-1-(2-chloro-5-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0 - 20℃;73.5%
2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

chloroacetyl chloride
79-04-9

chloroacetyl chloride

5-chloro-2-(2-chloroacetamido)-N,3-dimethylbenzamide
1374598-54-5

5-chloro-2-(2-chloroacetamido)-N,3-dimethylbenzamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 3.6h;73%
2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

C10H3BrCl2F2N2O

C10H3BrCl2F2N2O

3-bromo-N-(4-chloro-2-methyl-6-(methylcarbamoyl)phenyl)-1-(2-chloro-4,5-difluorophenyl)-1H-pyrazole-5-carboxamide

3-bromo-N-(4-chloro-2-methyl-6-(methylcarbamoyl)phenyl)-1-(2-chloro-4,5-difluorophenyl)-1H-pyrazole-5-carboxamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 12h;73%
2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

1-(pyrazin-2-yl)-3-bromo-1H-pyrazole-5-formyl chloride

1-(pyrazin-2-yl)-3-bromo-1H-pyrazole-5-formyl chloride

N-(2-(methylcarbamoyl)-4-chloro-6-methylphenyl)-3-bromo-1-(pyrazin-2-yl)-1H-pyrazole-5-carboxamide

N-(2-(methylcarbamoyl)-4-chloro-6-methylphenyl)-3-bromo-1-(pyrazin-2-yl)-1H-pyrazole-5-carboxamide

Conditions
ConditionsYield
With triethylamine In acetonitrile72%
2-amino-3-methyl-5-chlorobenzoyl-N-methylamine
890707-28-5

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

C9H6Cl2N4O2

C9H6Cl2N4O2

N-(2-(methylcarbamoyl)-4-chloro-6-methylphenyl)-3-methoxyl-1-(6-chloropyrazin-2-yl)-1H-pyrazole-5-carboxamide

N-(2-(methylcarbamoyl)-4-chloro-6-methylphenyl)-3-methoxyl-1-(6-chloropyrazin-2-yl)-1H-pyrazole-5-carboxamide

Conditions
ConditionsYield
With triethylamine In acetonitrile71%

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