892414-46-9Relevant articles and documents
TRICYCLIC DLK INHIBITORS AND USES THEREOF
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, (2016/09/26)
The invention relates to compounds of formula (I) and salts thereof, wherein ring A and R1-R2 have any of the values defined in the specification. The compounds and salts are useful for treating DLK mediated disorders. The invention also provides pharmaceutical compositions comprising a compound of formula (I), or a pharmaceutically acceptable salt thereof, as well as methods of using said compounds, salts, or compositions as DLK inhibitors and for treating neurodegeneration diseases and disorders.
Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-Like Proteins
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, (2011/11/30)
The present invention relates to novel compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and of diseases or conditions associated with amyloid-like proteins. The compounds of the present invention can also be used in the treatment of ocular diseases associated with pathological abnormalities/changes in the tissues of the visual system. The present invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the preparation of medicaments for treating or preventing diseases or conditions associated with amyloid and/or amyloid-like proteins. A method of treating or preventing diseases or conditions associated with amyloid and/or amyloid-like proteins is also disclosed.
Synthesis and derivatization of 3-perfluoroalkyl-substituted 7-azaindoles
Schirok, Hartmut,Figueroa-Perez, Santiago,Thutewohl, Michael,Paulsen, Holger,Kroh, Walter,Klewer, Dagmar
, p. 251 - 258 (2007/10/03)
An expedient large-scale synthesis of 3-perfluoroalkyl-7-azaindoles starting from 2-fluoropyridine is presented. The activation as 6-chloro-4-nitro derivative allows the further derivatization by nucleophilic aromatic substitution in the 4-position. Georg