892414-55-0

Basic information

• Product Name: BenzenaMine, 4-[[6-chloro-3-(trifluoroMethyl)-1-[[2-(triMethylsilyl)ethoxy]Methyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]oxy]-3,5-difluoro-
• Synonyms: BenzenaMine, 4-[[6-chloro-3-(trifluoroMethyl)-1-[[2-(triMethylsilyl)ethoxy]Methyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]oxy]-3,5-difluoro-;BenzenaMine, 4-[[6-chloro-3-(trifluoroMethyl)-1-[[2-(triMethylsilyl)ethoxy]Methyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]oxy]-3,5-difluoro-10;4-((6-Chloro-3-(trifluoromethyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)-3,5-difluoroaniline
• CAS NO: 892414-55-0
• Molecular Formula: C20H21ClF5N3O2Si
• Molecular Weight: 493.930156
• Mol File: 892414-55-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BenzenaMine, 4-[[6-chloro-3-(trifluoroMethyl)-1-[[2-(triMethylsilyl)ethoxy]Methyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]oxy]-3,5-difluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: BenzenaMine, 4-[[6-chloro-3-(trifluoroMethyl)-1-[[2-(triMethylsilyl)ethoxy]Methyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]oxy]-3,5-difluoro-(892414-55-0)
• EPA Substance Registry System: BenzenaMine, 4-[[6-chloro-3-(trifluoroMethyl)-1-[[2-(triMethylsilyl)ethoxy]Methyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]oxy]-3,5-difluoro-(892414-55-0)

Safety Data

• Hazardous Substances Data: 892414-55-0(Hazardous Substances Data)

Upstream product

• 892414-51-6 6-chloro-4-nitro-3-(trifluoromethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridine 
• 126058-97-7 2,6-di-fluoro-4-aminophenol 
• 892414-47-0 3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine 
• 892414-48-1 3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine 7-oxide 
• 932406-33-2 2,2,2-trifluoro-1-(2-fluoropyridin-3-yl)ethane-1,1-diol 
• 892414-46-9 3-(trifluoromethyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-3-ol 
• 892414-45-8 1,1,1-trifluoro-2-(2-fluoropyridin-3-yl)-3-nitropropan-2-ol 
• 892414-49-2 4-nitro-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine 7-oxide 
• 892414-50-5 6-chloro-4-nitro-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine 
• 372-48-5 2-fluoropyridine 

Relevant articles and documents

Improved synthesis of the selective rho-kinase inhibitor 6-chloro-n4-{3,5-difluoro-4-[(3-methyl-1h-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl} pyrimidin-2,4-diamine

A highly potent and selective Rho-kinase inhibitor containing a 7-azaindole moiety has been developed at Bayer Schering Pharma. Herein we disclose details of a significantly improved synthesis of the compound in 8.2% overall yield. Key aspects include cost and safety considerations and the uncommon use of a trifluoromethyl group with controllable reactivity as a masked methyl group.