896716-96-4

Basic information

• Product Name: (1S-cis)-(+/-)-4-[(2,5-DiaMino-6-chloro-4-pyriMidinyl)aMino]-2-cyclopentene-1-Methanol
• CAS NO: 896716-96-4
• Molecular Formula: C10H14ClN5O
• Molecular Weight: 255.70406
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 896716-96-4.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (1S-cis)-(+/-)-4-[(2,5-DiaMino-6-chloro-4-pyriMidinyl)aMino]-2-cyclopentene-1-Methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (1S-cis)-(+/-)-4-[(2,5-DiaMino-6-chloro-4-pyriMidinyl)aMino]-2-cyclopentene-1-Methanol(896716-96-4)
• EPA Substance Registry System: (1S-cis)-(+/-)-4-[(2,5-DiaMino-6-chloro-4-pyriMidinyl)aMino]-2-cyclopentene-1-Methanol(896716-96-4)

Safety Data

• Hazardous Substances Data: 896716-96-4(Hazardous Substances Data)

Upstream product

• 122624-75-3 (+/-)-cis-<4-<<2-amino-6-chloro-5-<(4-chlorophenyl)azo>-4-pyrimidinyl>amino>-2-cyclopentenyl>carbinol 
• 229177-39-3 1-amino-4-(hydroxymethyl)-2-cyclopentene 
• 61865-50-7 Acetic acid 4-acetylamino-cyclopent-2-enylmethyl ester 
• 122624-73-1 (+/-)-cis-<4-<(2-amino-6-chloro-4-pyrimidinyl)amino>-2-cyclopentenyl>carbinol 
• 141271-13-8 (1S,4R)-4-(<2'-amino-6'-chloro-5'-<(4''-chlorophenyl)azo>pyrimidin-4'-yl>amino)cyclopent-2-enylmethanol 
• 765-30-0 Cyclopropylamine 
• 171887-04-0 (1R,4S)-1-[(2-amino-6-chloro-5-formamido-4-pyrimidinyl)amino]-4-(hydroxymethyl)-2-cyclopentene 
• 79200-56-9 (-)-2-azabicyclo[2.2.1]hept-5-en-3-one 
• 136522-35-5 (1R,4S)-1-amino-4-hydroxymethyl-2-cyclopentene 
• 130931-86-1 (-)-(1S,4R)-4-acetamidocyclopent-2-enylmethanol 
• 127061-46-5 methyl (+)-cis-4-acetamidocyclopent-2-enecarboxylate 
• 141271-11-6 (-)-(1S,4R)-4-<(2'-amino-6'-chloropyrimidin-4'-yl)amino>-cyclopent-2-enylmethanol 
• 130931-84-9 (-)-(1S,4R)-4-aminocyclopent-2-ene-1-carboxylic acid hydrochloride 
• 229613-83-6 (–)-methyl (1S,4R)-4-aminocyclopent-2-ene-1-carboxylate hydrochloride 

Downstream Products

• 118353-05-2 (+/-)-cis-2-amino-1,9-dihydro-9-[4-(hydroxymethyl)-2-cyclopenten-1-yl]-6H-purin-6-one 
• 136522-33-3 (1S,4R)-4-[2-amino-6-chloro-9H-purin-9-yl]-2-cyclopentene-1-methanol 

Relevant articles and documents

ANTIVIRAL 4-(2-AMINO-6-HETEROCYLYL-9H-PURIN-9-YL)-2-CYCLOPENTENE-1 -METHANOL COMPOUNDS

The present invention relates to certain antiviral compounds of formula I as defined herein that function as nucleoside reverse transcriptase inhibitors. The present invention also relates to processes for the preparation of these compounds, pharmaceutical compositions comprising them and to their use for the treatment of retroviral infections, and in particular their use in the treatment of HIV-1 virus.

Process for the synthesis of chloropurine intermediates

The present invention relates to a process for the preparation of a carbocyclic purine nucleoside analogue of formula (I), its salts and pharmaceutically acceptable derivatives thereof which comprises hydrolysing a compound of formula (IV) wherein P is a protecting group, in the presence of an acid, condensing the product of formula (V) formed in situ in the presence of a base with a compound of formula (VI) followed by in situ ring closure of the resulting intermediate.

Method for producing 4-[2',5'-diamino-6'-halopyrimidine-4'-yl)amino]- cyclopent-2-enylmethanols

The invention relates to a novel method for producing 4-[(2′,5′-diamino-6′-halopyrimidine-4′-yl)amino]-cyclopent-2-enylmethanols of general formula (I), wherein X represents a halogen atom. According to the inventive method amino-4,6-halopyrimidine of general formula (II), wherein X has the aforementioned meaning, is reacted with a 4-aminocyclopent-2-enylmethanol of formula (III) or with a salt thereof in the presence of a base in a polar protic solvent.