899820-67-8

Basic information

• Product Name: 2,2-difluoro-1,1-diphenyl-2-(phenylsulfinyl)ethanol
• Synonyms: 2,2-difluoro-1,1-diphenyl-2-(phenylsulfinyl)ethanol
• CAS NO: 899820-67-8
• Molecular Weight: 358.409
• Mol File: 899820-67-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,2-difluoro-1,1-diphenyl-2-(phenylsulfinyl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-difluoro-1,1-diphenyl-2-(phenylsulfinyl)ethanol(899820-67-8)
• EPA Substance Registry System: 2,2-difluoro-1,1-diphenyl-2-(phenylsulfinyl)ethanol(899820-67-8)

Safety Data

• Hazardous Substances Data: 899820-67-8(Hazardous Substances Data)

Upstream product

• 536975-49-2 phenyl (trimethylsilyl)difluoromethyl sulfide 
• 119-61-9 benzophenone 
• 108-98-5 thiophenol 
• 1535-67-7 difluoromethyl phenyl sulfide 
• 24933-64-0 1-(difluoromethylsulfinyl)benzene 
• 878808-68-5 2,2-difluoro-1,1-diphenyl-2-(phenylsulfanyl)ethanol 

Downstream Products

• 569-72-2 1,1-difluoro-2,2-diphenylethylene 

Relevant articles and documents

Nucleophilic (phenylsulfinyl)difluoromethylation of carbonyl compounds with difluoromethyl phenyl sulfoxide

We have successfully achieved nucleophilic (phenylsulfinyl)difluoromethylation of both enolizable and non-enolizable aldehydes and ketones by using difluoromethyl phenyl sulfone (1) as the fluoroalkylating agent. Although the chemical yields of the reactions are good to excellent, the observed diastereoselectivity is poor (dr = 1:1.04-2.03). The present synthetic methodology provides a convenient alternative for the preparation of α-(phenylsulfinyl)difluoromethylated carbinols that were previously synthesized via a two-step procedure.