This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.
90-84-6Relevant articles and documents
Electrochemical, Iodine-Mediated α-CH Amination of Ketones by Umpolung of Silyl Enol Ethers
Strehl, Julia,Hilt, Gerhard
supporting information, p. 5968 - 5972 (2020/08/12)
The electrochemical, oxidative Umpolung reaction of silyl enol ethers utilizing simple iodide salts for the synthesis of α-amino ketones is described. The products were isolated in excellent yields of up to 100percent, and various functionalized starting materials were accepted in an undivided electrochemical cell design. Moreover, a sensitivity assessment to ensure an improved reproducibility of the reaction and cyclic voltammetry experiments were performed to postulate a plausible reaction mechanism on their basis.
A five coordination Cu(II) cluster-based MOF and its application in the synthesis of pharmaceuticals: Via sp3 C-H/N-H oxidative coupling
Tran, Thuan V.,Le, Hanh T. N.,Ha, Hiep Q.,Duong, Xuan N. T.,Nguyen, Linh H.-T.,Doan, Tan L. H.,Nguyen, Ha L.,Truong, Thanh
, p. 3453 - 3458 (2017/08/22)
Herein, a copper metal-organic framework, termed as VNU-18, containing penta-coordinated sites was successfully synthesized and fully characterized. This material was demonstrated to be an efficient heterogeneous catalyst for the oxidative C-H activation via N-H bonds. The optimized conditions are applicable for the synthesis of pharmaceuticals constructed by α-amino carbonyl skeletons.
Synthesis method of amfepramone hydrochloride drug intermediate 2-diethylamino-1-phenylacetone
-
Paragraph 0009-0010; 0018-0019, (2017/03/08)
The invention relates to a synthesis method of an amfepramone hydrochloride drug intermediate 2-diethylamino-1-phenylacetone, which comprises the following steps: adding 0.23 mol of alpha-aminophenylacetone into a reaction vessel which is provided with a stirrer, a thermometer, a reflux condenser and a dropping funnel, slowly adding 0.51-0.53 mol of diethylamine, heating the solution to 85-90 DEG C, reacting for 60-90 minutes, lowering the solution to 60-65 DEG C, adding 120ml of toluene, stirring for 60-80 minutes while controlling the stirring rate at 130-150 rpm, filtering, washing the filtrate with an oxalic acid solution, merging the extracting solutions, adding a potassium sulfite solution, regulating the pH value to 8-9, extracting with nitromethane 5-7 times, cooling the solution to 5-9 DEG C, precipitating a crystal, filtering, washing with a salt solution, washing with acetonitrile, and recrystallizing in cyclohexane to obtain the crystal 2-diethylamino-1-phenylacetone.