900505-17-1

Basic information

• Product Name: 4-(4-chloro-2-fluoro-benzyl)-3-(4-chloro-phenyl)-7-iodo-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione
• CAS NO: 900505-17-1
• Molecular Weight: 555.174
• Mol File: 900505-17-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(4-chloro-2-fluoro-benzyl)-3-(4-chloro-phenyl)-7-iodo-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-chloro-2-fluoro-benzyl)-3-(4-chloro-phenyl)-7-iodo-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione(900505-17-1)
• EPA Substance Registry System: 4-(4-chloro-2-fluoro-benzyl)-3-(4-chloro-phenyl)-7-iodo-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione(900505-17-1)

Safety Data

• Hazardous Substances Data: 900505-17-1(Hazardous Substances Data)

Upstream product

• 56456-49-6 (4-chloro-2-fluorophenyl)methanol 
• 536761-10-1 N-(4-chloro-2-fluoro-benzyl)phthalimide 
• 61072-56-8 4-chloro-2-fluorobenzaldehyde 
• 72235-57-5 (4-chloro-2-fluorophenyl)methanamine 

Relevant articles and documents

Novel 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists with improved cellular activity

The disruption of the p53-Hdm2 protein-protein interaction induces cell growth arrest and apoptosis. We have identified the 1,4-benzodiazepine-2,5-dione scaffold as a suitable template for inhibiting this interaction by binding to the Hdm2 protein. Several compounds have been made with improved potency, solubility, and cell-based activities.