900811-48-5Relevant articles and documents
PROCESS FOR PREPARING 8-ARYLOCTANOIC ACIDS
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, (2015/02/02)
The present invention relates to a process for preparing aliskiren and, more particularly, to an improved method for synthesizing a β-amino alcohol or a lactone analog thereof via the corresponding nitro derivatives of formula (Ia) or (Ib) these intermediates being used in the preparation of aliskiren.
Metal-Free Reduction of Aromatic and Aliphatic Nitro Compounds to Amines: A HSiCl3-Mediated Reaction of Wide General Applicability
Orlandi,Tosi,Bonsignore,Benaglia
supporting information, p. 3941 - 3943 (2015/09/01)
A new, mild, metal-free, HSiCl3-mediated reduction of both aromatic and aliphatic nitro groups to amines that is of wide general applicability, tolerant of many functional groups, and respectful of the stereochemical integrity of stereocenters is reported.
PROCESS FOR THE PREPARATION OF ALISKIREN
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, (2013/05/21)
The present invention provides a novel process and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren, or a salt thereof, preferably Aliskiren hemifumarate.