90101-22-7

Basic information

• Product Name: 2-(BOC-AMINO)-6-PICOLINE
• Synonyms: 2-(BOC-AMINO)-6-PICOLINE;TERT-BUTYL 6-METHYLPYRIDIN-2-YLCARBAMATE;Carbamic acid, (6-methyl-2-pyridinyl)-, 1,1-dimethylethyl ester (9CI);2-Amino-6-methylpyridine, N-BOC protected;2-Amino-6-picoline, N-BOC protected;2-Amino-6-methylpyridine, 2-BOC protected 97%;tert-Butyl (6-methylpyridin-2-yl)carbamate, 2-Amino-6-picoline, 2-BOC protected;tert-butyl 6-Methylpyridine-2-ylcarbaMate
• CAS NO: 90101-22-7
• Molecular Formula: C₁₁H₁₆N₂O₂
• Molecular Weight: 208.26
• Product Categories: N-BOC
• Mol File: 90101-22-7.mol
• Article Data: 32

Chemical Properties

• Melting Point: 63-64°C
• Boiling Point: 261.4°Cat760mmHg
• Flash Point: 111.9°C
• Appearance: /
• Density: 1.108g/cm³
• Vapor Pressure: 0.0116mmHg at 25°C
• Refractive Index: 1.54
• Storage Temp.: 2-8°C
• PKA: 12.56±0.70(Predicted)
• CAS DataBase Reference: 2-(BOC-AMINO)-6-PICOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(BOC-AMINO)-6-PICOLINE(90101-22-7)
• EPA Substance Registry System: 2-(BOC-AMINO)-6-PICOLINE(90101-22-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-43
• Safety Statements: 36/37
• WGK Germany: 3
• Hazardous Substances Data: 90101-22-7(Hazardous Substances Data)

Usage

General Description

2-(BOC-AMINO)-6-PICOLINE is a chemical compound with the molecular formula C12H16N2O2. It is often used as a building block in organic synthesis and pharmaceutical research. The compound is a derivative of picoline, a heterocyclic aromatic compound. The “BOC” in its name stands for tert-butyloxycarbonyl, which is a protecting group used in organic chemistry to temporarily mask reactive functional groups. 2-(BOC-AMINO)-6-PICOLINE is widely used as a reagent in the synthesis of various drugs and pharmaceuticals due to its versatile reactivity and potential for selective functionalization. Its use in the pharmaceutical industry is expanding, and it is an important intermediate in the production of various bioactive compounds.

InChI:InChI=1/C11H16N2O2/c1-8-6-5-7-9(12-8)13-10(14)15-11(2,3)4/h5-7H,1-4H3,(H,12,13,14)

Upstream product

• 1824-81-3 2-Amino-6-methylpyridine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 75-09-2 dichloromethane 
• 121-44-8 triethylamine 
• 34619-03-9 tert-butyldicarbonate 
• 75-44-5 phosgene 
• 75-65-0 tert-butyl alcohol 

Downstream Products

• 205676-84-2 (tert-butoxy)-N-methyl-N-[6-methyl-(2-pyridyl)]carboxamide 
• 408365-87-7 ethyl 2-(6-((tert-butoxycarbonyl)amino)pyridin-2-yl)acetate 
• 582308-81-4 2-(6-tert-Butoxycarbonylamino-3-chloro-pyridin-2-yl)-acetic acid 
• 582308-86-9 2-[3-chloro-6-(2,2-difluoro-2-pyridin-2-yl-ethylamino)-pyridin-2-yl]-N-(3-chlorobenzyl)-acetamide 
• 582309-07-7 N-(2-aminomethyl-benzyl)-2-[3-chloro-6-(2,2-difluoro-2-pyridin-2-yl-ethylamino)-pyridin-2-yl]-acetamide 
• 582308-66-5 2-[6-(2,2-difluoro-2-pyridin-2-yl-ethylamino)-pyridin-2-yl]-N-(2-aminomethyl-5-chloro-benzyl)-acetamide 
• 582308-68-7 2-[6-(2,2-difluoro-2-pyridin-2-yl-ethylamino)-pyridin-2-yl]-N-(5-chloro-2-tetrazol-1-yl-benzyl)-acetamide 
• 582308-70-1 2-[6-(2,2-difluoro-2-pyridin-2-yl-ethylamino)-pyridin-2-yl]-N-(5-chloro-2-[1,2,4]triazol-1-yl-benzyl)-acetamide 

Relevant articles and documents

ARYL AND HETEROARYL-CARBOXAMIDE SUBSTITUTED HETEROARYL COMPOUNDS AS TYK2 INHIBITORS

Novel carboxamide substituted compounds of Formula (I) are disclosed; as well as processes for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Tyrosine Kinase 2 (Tyk2).

QUINOLONE DERIVATIVES AS FIBROBLAST GROWTH FACTOR INHIBITORS

Compounds of formula (Ι') that are Fibroblast Growth Factor Inhibitors (FGFR) and are therefore useful for the treatment of diseases treatable by inhibition of FGFR are disclosed. Also disclosed are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

PROCESS FOR PREPARATION OF t-BUTOXYCARBONYLAMINE COMPOUNDS

Provided is a process for the preparation of t-butoxycarbonylamine compounds, which comprises using phosgene or a phosgene equivalent, t-butanol, and an organic base. Even when applied to a primary or secondary amine compound having low nucleophilicity, the process enables highly selective preparation of a t-butoxycarbonylamine compound at a low cost. In the process, a t-butoxycarbonylamine compound is prepared using: phosgene or a phosgene equivalent; t-butanol; an organic base; and either a primary or secondary amine compound or a primary or secondary ammonium salt.