90237-08-4Relevant articles and documents
In vivo and in vitro behaviour of 2-allophanyl-2-(2-methylpropyl) γ-valerolactone: Comparison with corresponding hydroxybarbiturate
Lafont,Cave,Lambrey,et al.
, p. 17 - 21 (2007/10/02)
The little compound is studied in vitro, under biomimetic conditions. An equilibrium between this monoureide and a barbiturate-alcohol is detected, but the title compound also undergoes hydrolysis into a carboxylic lactone and urea. Its behaviour is then studied in rats and dogs. The compounds obtained in vitro are present in urine, but spirobilactonic derivatives are also isolated. They indicate that hepatic hydroxylation took place. Comparison with results obtained with the corresponding hydroxybarbiturate shows that the equilibrium is too slow to make the title compound disappear from biologic media, before its hydrolysis, but fast enough to form the barbiturate which can then be hydroxylated by the liver. This behaviour is different from that of valofan-proxibarbal which does not undergo hepatic metabolization because lipophilicity of proxibarbal is insufficient.
