903513-58-6

Basic information

• Product Name: 4-bromo-2,6-difluoropyridine
• Synonyms: 4-bromo-2,6-difluoropyridine
• CAS NO: 903513-58-6
• Molecular Formula: C₅H₂BrF₂N
• Molecular Weight: 194
• Mol File: 903513-58-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 197.7±35.0 °C(Predicted)
• Appearance: /
• Density: 1.808±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -1.72±0.10(Predicted)
• CAS DataBase Reference: 4-bromo-2,6-difluoropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-2,6-difluoropyridine(903513-58-6)
• EPA Substance Registry System: 4-bromo-2,6-difluoropyridine(903513-58-6)

Safety Data

• Hazardous Substances Data: 903513-58-6(Hazardous Substances Data)

Usage

General Description

4-bromo-2,6-difluoropyridine is a chemical compound with the molecular formula C5H2BrF2N. It is a pyridine derivative that contains a bromine atom and two fluorine atoms. 4-bromo-2,6-difluoropyridine is used as a building block in the synthesis of various pharmaceutical and agrochemical products. It is also used as an intermediate in the production of organic compounds and has applications in the field of medicinal chemistry. 4-bromo-2,6-difluoropyridine is a highly versatile and important chemical in the industry, and its unique properties make it a valuable tool for scientists and researchers in the development of new materials and products.

Upstream product

• 837364-94-0 2,6-difluoro-4-hydrazinylpyridine 
• 3512-17-2 2,4,6-trifluoropyridine 
• 1513-65-1 2,6-difluoro pyridine 
• 1204333-58-3 2,6-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 

Downstream Products

• 401816-16-8 (2,6-difluoropyridin-4-yl)boronic acid 
• 1217182-57-4 C₃₈H₄₅N₇O₈ 
• 1217182-65-4 C₄₀H₄₇N₇O₁₀ 
• 1151683-57-6 C₄₃H₅₃N₇O₁₁ 
• 337917-96-1 2,6-bis(3'-hydroxymethyl-1'-pyrazolyl)-4-phenylpyridine 
• 337917-97-2 2,6-bis(3'-bromomethyl-1'-pyrazolyl)-4-phenylpyridine 

Relevant articles and documents

METHODS AND COMPOSITIONS FOR MODULATING SPLICING

Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

AMINOPYRAZOLES AS SELECTIVE JANUS KINASE INHIBITORS

The instant invention provides compounds of formula I which are selective JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as atopic dermatitis, arthritis, and cancer.

Substituted pyridines

A class of 2,4-; 2,3,4-; 2,4,6-; 2,3,4,5,6-substituted pyridines is provided which include novel compounds. The substitutions are achieved according to methods disclosed herein in which a metallated pyridine is reacted with an electrophile. Suitable electrophiles include CO2, SO2, dialkylcarbonates, ureas, formamides, amides, carboxylic acid esters, mono- and dihaloalkyls, halogens such as chlorine, fluorine, bromine, and iodine, metallic salts, sulfones, sulfonyls, aldehydes, ketones, anhydrides, nitrites, and electrophilic boron compounds including, but not limited to, boron trialkoxides and boron trihalides. The subject invention more specifically discloses a process for the synthesis of 2,6-difluoropyridin-4-ylboronic acid which comprises: (1) reacting 2,4,6-trifluoropyridine with hydrazine monohydrate to produce 2,6-difluoro-4-hydrazinopyridine, (2) reacting the 2,6-difluoro-4-hydrazinopyridine with elemental bromine to produce 4-bromo-2,6-difluoropyridine, and (3) reacting the 4-bromo-2,6-difluoropyridine with an organolithium compound and a borate at a temperature of less than about 0° C. to produce the 2,6-difluoropyridin-4-ylboronic acid, wherein said process is conducted in an organic solvent.