90481-67-7

Basic information

• Product Name: Phosphonium, [(2-bromo-6-nitrophenyl)methyl]triphenyl-, bromide
• CAS NO: 90481-67-7
• Molecular Formula: C25H20BrNO2P.Br
• Molecular Weight: 557.221
• Mol File: 90481-67-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Phosphonium, [(2-bromo-6-nitrophenyl)methyl]triphenyl-, bromide(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonium, [(2-bromo-6-nitrophenyl)methyl]triphenyl-, bromide(90481-67-7)
• EPA Substance Registry System: Phosphonium, [(2-bromo-6-nitrophenyl)methyl]triphenyl-, bromide(90481-67-7)

Safety Data

• Hazardous Substances Data: 90481-67-7(Hazardous Substances Data)

Upstream product

• 603-83-8 3-nitro-o-tolylamine 
• 55289-35-5 2-bromo-6-nitrotoluene 
• 58579-54-7 3-bromo-2-(bromomethyl)-1-nitrobenzene 
• 603-35-0 triphenylphosphine 

Downstream Products

• 88299-06-3 (E)-2-methyl-4-(1-tosyl-1H-indol-4-yl)but-3-en-2-ol 
• 90481-76-8 4-(2-phthalimidoethen-1-yl)-1-tosylindole 
• 90481-73-5 (E)-methyl 3-(1-tosyl-1H-indol-4-yl)acrylate 
• 90481-75-7 4-(2-phenylethen-1-yl)-1-tosylindole 
• 90481-78-0 3,4-dibromo-1-tosylindole 
• 90481-71-3 N-tosyl-3-bromo-2-ethenylaniline 
• 90481-70-2 3-bromo-2-ethenylacetanilide 
• 90481-69-9 3-bromo-2-ethenylaniline 
• 90481-72-4 4-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indole 
• 52488-36-5 4-bromo-1H-indole 
• 90481-68-8 1-bromo-2-ethenyl-3-nitrobenzene 

Relevant articles and documents

Palladium-Catalyzed Reactions in the Synthesis of 3- and 4-Substituted Indoles. Approaches to Ergot Alkaloids

An efficient synthesis of 4-bromo-1-tosylindole (10) based on the Pd(II)-catalyzed cyclization of an o-ethenylaniline p-toluenesulfonamide has been developed.A Pd(0) oxidative addition-olefin insertion-β-hydride elimination cycle converted 10 to a number of 4-substituted 1-tosylindoles.Selective electrophilic substitutions at the 3-position of 10 provided access to the 3-(chloromercurio)- (18) and 3-iodo-1-tosylindoles (22).Transmetalation to palladium and allyl chloride insertion converted 18 to 3-allyl-4-bromo-1-tosylindole (20) which could be cyclized to the benzindoline 21.A Pd(0) oxidative addition-olefin insertion-β-hydride elimination cycle converted the 3-iodo compound 22 to a number of 4-bromo-3-substituted 1-tosylindoles including 24, a potential precursor to optically active tryptophans.