90481-73-5Relevant articles and documents
Application of a One-Pot Friedel–Crafts Alkylation/Michael Addition Methodology to the Asymmetric Synthesis of Ergoline Derivatives
Despotopoulou, Christina,McKeon, Sean C.,Connon, Robert,Coeffard, Vincent,Müller-Bunz, Helge,Guiry, Patrick J.
, p. 6734 - 6738 (2017)
Herein, we report a short and facile stereoselective route to ergoline derivatives. The key steps are a one-pot Friedel–Crafts alkylation/Michael addition sequence which, in the absence of chiral ligands, affords the trans-trans-stereoisomer in 44 % yield