90513-09-0Relevant articles and documents
From Kinase Inhibitors to Multitarget Ligands as Powerful Drug Leads for Alzheimer's Disease using Protein-Templated Synthesis
Nozal, Vanesa,García-Rubia, Alfonso,Cuevas, Eva P.,Pérez, Concepción,Tosat-Bitrián, Carlota,Bartolomé, Fernando,Carro, Eva,Ramírez, David,Palomo, Valle,Martínez, Ana
, p. 19344 - 19354 (2021)
Multitarget directed ligands (MTDLs) are arising as promising tools to tackle complex diseases. The main goal of this work is to create powerful modulating agents for neurodegenerative disorders. To achieve this aim, we have combined fragments that inhibi
Spherical Supramolecular Structures Constructed via Chemically Symmetric Perylene Bisimides: Beyond Columnar Assembly
Cheng, Stephen Z. D.,Cui, Yunpeng,Feng, Xueyan,Guo, Qing-Yun,Huang, Jiahao,Huang, Mingjun,Li, Xiaopeng,Liu, Tong,Liu, Yuchu,Shan, Wenpeng,Shi, An-Chang,Su, Zebin,Wang, Jian,Yan, Xiao-Yun,Zhang, Rongchun,Zhang, Rui,Zhang, Ruimeng
supporting information, p. 18563 - 18571 (2020/08/24)
Like other discotic molecules, self-assembled supramolecular structures of perylene bisimides (PBIs) are commonly limited to columnar or lamellar structures due to their distinct π-conjugated scaffolds and unique rectangular shape of perylene cores. The discovery of PBIs with supramolecular structures beyond layers and columns may expand the scope of PBI-based materials. A series of unconventional spherical packing phases in PBIs, including A15 phase, σ phase, dodecagonal quasicrystalline (DQC) phase, and body-centered cubic (BCC) phase, is reported. A strategy involving functionalization of perylene core with several polyhedral oligomeric silsesquioxane (POSS) cages achieved spherical assemblies of PBIs, instead of columnar assemblies, due to the significantly increased steric hindrance at the periphery. This strategy may also be employed for the discovery of unconventional spherical assemblies in other related discotic molecules by the introduction of similar bulky functional groups at their periphery. An unusual inverse phase transition sequence from a BCC phase to a σ phase was observed by increasing annealing temperature.
Novel phenethanolamines
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, (2008/06/13)
The tertiary amines of the formula STR1 wherein n represents a whole number of 1 to 5; X1 represents phenyl or phenyl mono-, di- or tri-substituted by R1, R2 and R3 ; X2 represents hydrogen, lower-alkyl, phenyl or phenyl mono-, di- or tri-substituted by R1, R2 and R3 ; Y represents hydrogen, lower-alkyl, hydroxymethyl, carboxy or lower-alkoxycarbonyl; Z represents a group of the formula STR2 R1, R2 and R3 represent hydrogen, halogen, hydroxy, benzyloxy, lower-alkyl, lower-alkoxy, hydroxymethyl, amino, acylamino, lower-alkoxybenzylamino, nitro, carbamoyl, trifluoromethyl or lower-alkylsulphonylmethyl; R4, R5 and R51 represent hydrogen, lower-alkyl, lower-alkoxy, lower alkanoyl, carboxy, cyano, hydroxy, hydroxy-lower-alkyl, acyloxy or a group --C(R6)=C(R7)COOR8, --SO2 R9, --C(O)R9 or --CH2 R10, with the proviso that R4 does not represent hydrogen when R5 represents hydroxy, lower-alkyl or lower-alkoxy; R6, R7 and R8 represent hydrogen or lower-alkyl; R9 represents amino, mono-lower-alkylamino or a group R; R represents di-lower-alkylamino, piperidino, morpholino, thiamorpholino, piperazino or the ether group of a lower aliphatic, cycloaliphatic or araliphatic alcohol or of a phenol; and R10 represents a group R and, where R1, R2 and R3 represent hydrogen, halogen, hydroxy, benzyloxy, lower-alkyl, lower-alkoxy, hydroxymethyl, amino, lower-alkoxybenzylamino or trifluoromethyl and simultaneously Y represents hydrogen, lower-alkyl or hydroxymethyl, R10 can also represent amino or mono-lower-alkylamino, have hypoglycaemic activity and reduce glycosuria. They are manufactured from corresponding primary or secondary amines.
