90956-80-2

Basic information

• Product Name: 3-AMINO-3-(3-CHLOROPHENYL)-2-PROPENOIC ACID ETHYL ESTER
• Synonyms: 3-AMINO-3-(3-CHLOROPHENYL)-2-PROPENOIC ACID ETHYL ESTER
• CAS NO: 90956-80-2
• Molecular Formula: C₁₁H₁₂ClNO₂
• Molecular Weight: 225.674
• Mol File: 90956-80-2.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-AMINO-3-(3-CHLOROPHENYL)-2-PROPENOIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-3-(3-CHLOROPHENYL)-2-PROPENOIC ACID ETHYL ESTER(90956-80-2)
• EPA Substance Registry System: 3-AMINO-3-(3-CHLOROPHENYL)-2-PROPENOIC ACID ETHYL ESTER(90956-80-2)

Safety Data

• Hazardous Substances Data: 90956-80-2(Hazardous Substances Data)

Upstream product

• 766-84-7 3-chloro-benzonitrile 
• 105-36-2 ethyl bromoacetate 
• 33167-21-4 3-(3-chloro-phenyl)-3-oxo-propionic acid ethyl ester 

Downstream Products

• 1450828-36-0 ethyl 2-(3-chlorophenyl)nicotinate 
• 498581-88-7 3-amino-3-(3-chloro-phenyl)-propionic acid ethyl ester 
• 498581-88-7 ethyl (3R)-3-amino-3-(3-chlorophenyl)propanoate 
• 1159577-08-8 ethyl 2-(3-chlorophenyl)-5-hydroxy-1H-benzo[g]indole-3-carboxylate 

Relevant articles and documents

Synthesis of Thiazoles and Isothiazoles via Three-Component Reaction of Enaminoesters, Sulfur, and Bromodifluoroacetamides/Esters

A three-component strategy for the synthesis of thiazoles and isothiazoles has been developed by employing enaminoesters, fluorodibromoiamides/ester, and sulfur. The thiazoles and isothiazoles were formed via two C-F bond cleavages along with the formation of new C-S, C-N, and N-S bonds. The strategy provides high selectivity for the synthesis of thiazoles/isothiazoles, which have vital applications in drug discovery and development.

Divergent Synthesis of Multisubstituted Unsymmetric Pyrroles and Pyrrolin-4-ones from Enamino Esters via Copper-Catalyzed Aerobic Dimerization

A facile synthetic method to access multisubstituted unsymmetric pyrrole and pyrrolin-4-one derivatives is disclosed. In the presence of Cu(OAc)2 and KOAc, substituted pyrrole derivatives are produced in good yields (up to 93 %) through oxidative cyclization of enamino esters. Meanwhile, using CuCl2 and TFA (trifluoroacetic acid), pyrrolin-4-one derivatives are obtained in excellent yields (up to 94 %) through 1,2-aryl migration. A wide range of functional groups have been tolerated, and a reliable method for the synthesis of valuable multisubstituted pyrroles and pyrrolin-4-ones has been developed.

Copper-Catalyzed Tandem Reaction of Enamino Esters with ortho-Halogenated Aromatic Carbonyls: One-Pot Approach to Functionalized Quinolines

An efficient and practical approach for the synthesis of functionalized quinolines has been developed by using the copper-catalyzed tandem C–C bond formation and C–N coupling reaction of enamino esters and ortho-halogenated aromatic carbonyl compounds. Various functional groups were tolerated under the reaction conditions, and a series of quinolines were easily obtained in moderate to good yields. A gram-scale reaction was also performed to demonstrate a further application of this synthetic method.