910875-39-7 Usage
General Description
3-Phenylpiperidin-4-one monohydrochloride is a chemical compound that belongs to the class of piperidine derivatives. It is commonly used in chemical and pharmaceutical research as a building block in the synthesis of various compounds, particularly in the development of new drugs. 3-Phenylpiperidin-4-one monohydrochloride is also known for its analgesic properties and has been the subject of interest for its potential as a pain-relief medication. Additionally, it has been found to exhibit activity as a dopamine receptor antagonist, making it a target for studying its effects on the central nervous system. 3-Phenylpiperidin-4-one monohydrochloride is a versatile and valuable chemical with potential applications in medical and scientific fields.
Check Digit Verification of cas no
The CAS Registry Mumber 910875-39-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,0,8,7 and 5 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 910875-39:
(8*9)+(7*1)+(6*0)+(5*8)+(4*7)+(3*5)+(2*3)+(1*9)=177
177 % 10 = 7
So 910875-39-7 is a valid CAS Registry Number.
910875-39-7Relevant articles and documents
Design, structure-activity relationship, and highly efficient asymmetric synthesis of 3-phenyl-4-benzylaminopiperidine derivatives as novel neurokinin-1 receptor antagonists
Shirai, Junya,Yoshikawa, Takeshi,Yamashita, Masayuki,Yamamoto, Yasuharu,Kawamoto, Makiko,Tarui, Naoki,Kamo, Izumi,Hashimoto, Tadatoshi,Ikeura, Yoshinori
experimental part, p. 6430 - 6446 (2011/12/01)
We synthesized a series of novel 3-phenyl-4-benzylaminopiperidine derivatives that were identified as potent tachykinin NK1 receptor antagonists by structural modification of the 3-benzhydrylpiperidone derivative through high-throughput screening. N-{2-[(3R,4S)-4-({2-Methoxy-5-[5-(trifluoromethyl)- 1Htetrazol-1-yl]benzyl}amino)-3-phenyl-1-piperidinyl]-2-oxoethyl}acetamide ((+)-39) was found to be one of the most potent tachykinin NK1 receptor antagonists with high metabolic stability. Highly efficient asymmetric synthesis of (+)-39 was achieved via dynamic kinetic resolution.
