911066-06-3

Basic information

• Product Name: N-[2-acetylamino-5-(3,4,5-trimethoxy-benzoyl)-pyrimidin-4-yl]-acetamide
• CAS NO: 911066-06-3
• Molecular Weight: 388.38
• Mol File: 911066-06-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[2-acetylamino-5-(3,4,5-trimethoxy-benzoyl)-pyrimidin-4-yl]-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-acetylamino-5-(3,4,5-trimethoxy-benzoyl)-pyrimidin-4-yl]-acetamide(911066-06-3)
• EPA Substance Registry System: N-[2-acetylamino-5-(3,4,5-trimethoxy-benzoyl)-pyrimidin-4-yl]-acetamide(911066-06-3)

Safety Data

• Hazardous Substances Data: 911066-06-3(Hazardous Substances Data)

Upstream product

• 738-70-5 5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine 
• 500900-39-0 (N,N'-(5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diyl)diacetamide) 

Relevant articles and documents

Novel pyrimidine derivatives for drug design

TRIMETHOPRIM [2,4-diamino-5-(3,4,5-trimethoxybenzyl) pyrimidine] (1 a) reacted with benzaldehyde and acetic anhydride to afford 2,4-disubstituted amino derivatives (1b-c). The methylene group of compounds (1a-c) was oxidized by convenient and simple method using sodium dichromate and acetic acid to give the corresponding ketonic derivatives (2a-c). (2a) was converted to the corresponding thio derivative using phosphrous pentasulphide or Lawsson's reagent which is the target of our work. The reaction of ketonic derivatives (2a-c) with different nitrogen nucleophiles have been also reported.