500900-39-0

Basic information

• Product Name: (N,N'-(5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diyl)diacetamide)
• Synonyms: (N,N'-(5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diyl)diacetamide)
• CAS NO: 500900-39-0
• Molecular Weight: 374.396
• Mol File: 500900-39-0.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: (N,N'-(5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diyl)diacetamide)(CAS DataBase Reference)
• NIST Chemistry Reference: (N,N'-(5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diyl)diacetamide)(500900-39-0)
• EPA Substance Registry System: (N,N'-(5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diyl)diacetamide)(500900-39-0)

Safety Data

• Hazardous Substances Data: 500900-39-0(Hazardous Substances Data)

Upstream product

• 75-36-5 acetyl chloride 
• 738-70-5 5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine 
• 108-24-7 acetic anhydride 

Downstream Products

• 192314-93-5 iclaprim 
• 911066-06-3 N-[2-acetylamino-5-(3,4,5-trimethoxy-benzoyl)-pyrimidin-4-yl]-acetamide 

Relevant articles and documents

A novel and practical synthesis of Iclaprim

A novel and facile synthesis of Iclaprim was reported. Started from trimethoprim (TMP), the amino-protection and Friedel–Crafts acetylation with acetic anhydride were simultaneously completed in CH2Cl2 with SnCl4 as cataly

Preparation method of iclaprim intermediate

The invention discloses a preparation method of an iclaprim intermediate. The invention discloses a preparation method of an acetamide compound represented by a formula 1a, wherein the preparation method comprises the following steps: performing acetylati

Iclaprim intermediate and applications thereof

The invention discloses an iclaprim intermediate and applications thereof. The invention discloses a benzodihydropyrone compound shown as formula 5 or a salt thereof. The benzopyrone compound as shownin formula 5 or the salt thereof is used as a new intermediate of iclaprim for preparing iclaprim. A preparation method comprises the following steps: in an organic solvent, under the action of a reduction reagent, carrying out reduction reaction on the benzodihydropyrone compound as shown in formula 5 and/or a salt of the benzodihydropyrone compound as shown in formula 5 to obtain a benzodihydropyrane compound shown as formula 6, wherein the reducing reagent is sodium borohydride and/or potassium borohydride. When the iclaprim intermediate is used for preparing iclaprim, the used reagents are more economical, the route is short, the yield is high, the preparation cost is low, the post-treatment is simple, and the iclaprim intermediate is suitable for industrial production.