192314-93-5

Basic information

• Product Name: 5-[(2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)methyl]pyrimidine-2,4- diamine
• Synonyms: 5-[(2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)methyl]pyrimidine-2,4- diamine;iclaprim;5-[(2-Cyclopropyl-7,8-diMethoxy-2H-1-benzopyran-5-yl)Methyl]-2,4-pyriMidine- diaMine;AR 100;5-(2-Cyclopropyl-7,8-dimethoxy-2H-chromen-5-ylmethyl)-pyrimidine-2,4-diamine (ICLAPRIM];5-((2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)methyl)pyrimidine-2,4-diamine(WXG01982)
• CAS NO: 192314-93-5
• Molecular Formula: C19H22N4O3
• Molecular Weight: 354.408
• Product Categories: Amines;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 192314-93-5.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 616.7°Cat760mmHg
• Flash Point: 326.8°C
• Appearance: /
• Density: 1.332g/cm³
• Vapor Pressure: 3.84E-15mmHg at 25°C
• Refractive Index: 1.665
• PKA: 7.07±0.10(Predicted)
• Water Solubility: 14g/L at 20℃
• CAS DataBase Reference: 5-[(2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)methyl]pyrimidine-2,4- diamine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[(2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)methyl]pyrimidine-2,4- diamine(192314-93-5)
• EPA Substance Registry System: 5-[(2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)methyl]pyrimidine-2,4- diamine(192314-93-5)

Safety Data

• Hazardous Substances Data: 192314-93-5(Hazardous Substances Data)

Usage

Description

5-[(2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)methyl]pyrimidine-2,4-diamine is a complex organic compound characterized by its unique molecular structure. It is derived from a combination of a cyclopropyl-chromen moiety and a pyrimidine-2,4-diamine group, which may contribute to its potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
5-[(2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)methyl]pyrimidine-2,4-diamine is used as a potential therapeutic agent for the treatment of various medical conditions. Its unique molecular structure may allow it to interact with specific biological targets, making it a promising candidate for the development of new drugs.
Used in Antibacterial Applications:
5-[(2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)methyl]pyrimidine-2,4-diamine is used as a novel antibacterial agent for the treatment of complicated skin and skin structure infections (cSSSI). Its specific mode of action and potential to combat antibiotic-resistant bacteria make it a valuable addition to the arsenal of antibiotics.
Used in Drug Delivery Systems:
In order to enhance the efficacy and bioavailability of 5-[(2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)methyl]pyrimidine-2,4-diamine, researchers may develop innovative drug delivery systems. These systems could include organic and metallic nanoparticles as carriers, aiming to improve the compound's delivery, bioavailability, and therapeutic outcomes in various applications.

InChI:InChI=1/C19H22N4O3/c1-24-15-8-11(7-12-9-22-19(21)23-18(12)20)13-5-6-14(10-3-4-10)26-16(13)17(15)25-2/h5-6,8-10,14H,3-4,7H2,1-2H3,(H4,20,21,22,23)

Upstream product

• 192315-08-5 (RS)-3-anilino-2-(2-cyclopropyl-7,8-dimethoxy-2H-1-benzopyran-5-yl-methyl)acrylonitrile 
• 865-47-4 potassium tert-butylate 
• 50-01-1 guanidine hydrochloride 
• 738-70-5 5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine 
• 500900-39-0 (N,N'-(5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diyl)diacetamide) 
• 906797-55-5 N-{5-[2-(3-cyclopropyl-3-oxo-propenyl)-4,5-dimethoxy-3-methoxymethoxy-benzyl]-4-isobutyrylamino-pyrimidin-2-yl}-isobutyramide 
• 906797-57-7 N-{5-[2-(3-cyclopropyl-3-hydroxy-propenyl)-4,5-dimethoxy-3-methoxymethoxy-benzyl]-4-isobutyrylamino-pyrimidin-2-yl}-isobutyramide 

Relevant articles and documents

A seven-membered heterocyclic compound or a salt thereof. Preparation method and application thereof

The invention discloses a seven-membered heterocyclic compound or a salt thereof as well as a preparation method and application thereof. The invention provides a seven-membered heterocyclic compound represented by a formula 7a or a salt thereof. The inve

Iclaprim p-toluenesulfonate and preparation method and application thereof

The invention discloses an iclaprim p-toluenesulfonate and a preparation method and application thereof. The preparation method of the iclaprim p-toluenesulfonate as shown in a formula 7a is disclosed. The preparation method comprises the following steps that in an aprotic solvent and under the action of p-toluenesulfonic acid, a benzodihydropyran compound as shown in a formula 6 is subjected to an elimination reaction to obtain the iclaprim p-toluenesulfonate as shown in the formula 7a. The aprotic solvent is one or more of tetrahydrofuran, methyltetrahydrofuran, acetone, dimethylformamide and dimethylsulfoxide. By using the iclaprim p-toluenesulfonate as an intermediate to prepare iclaprim, a reagent used is more economical, a route is short, the yield is high, the preparation cost is low, the aftertreatment is simple, and the iclaprim p-toluenesulfonate is suitable for industrial production.

Iclaprim intermediate and applications thereof

The invention discloses an iclaprim intermediate and applications thereof. The invention discloses a benzodihydropyrone compound shown as formula 5 or a salt thereof. The benzopyrone compound as shownin formula 5 or the salt thereof is used as a new intermediate of iclaprim for preparing iclaprim. A preparation method comprises the following steps: in an organic solvent, under the action of a reduction reagent, carrying out reduction reaction on the benzodihydropyrone compound as shown in formula 5 and/or a salt of the benzodihydropyrone compound as shown in formula 5 to obtain a benzodihydropyrane compound shown as formula 6, wherein the reducing reagent is sodium borohydride and/or potassium borohydride. When the iclaprim intermediate is used for preparing iclaprim, the used reagents are more economical, the route is short, the yield is high, the preparation cost is low, the post-treatment is simple, and the iclaprim intermediate is suitable for industrial production.