915118-02-4

Basic information

• Product Name: N-(diphenylmethylene)-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]-L-phenylalanine tert-butyl ester
• Synonyms: N-(diphenylmethylene)-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]-L-phenylalanine tert-butyl ester
• CAS NO: 915118-02-4
• Molecular Weight: 493.529
• Mol File: 915118-02-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(diphenylmethylene)-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]-L-phenylalanine tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-(diphenylmethylene)-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]-L-phenylalanine tert-butyl ester(915118-02-4)
• EPA Substance Registry System: N-(diphenylmethylene)-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]-L-phenylalanine tert-butyl ester(915118-02-4)

Safety Data

• Hazardous Substances Data: 915118-02-4(Hazardous Substances Data)

Upstream product

• 73899-14-6 3-phenyl-3-(trifluoromethyl)-3H-diazirine 
• 87736-88-7 3-[4-(hydroxymethyl)phenyl]-3-trifluoromethyl-3H-diazirine 
• 128886-88-4 4-<3-trifluoromethyl-3H-diazirin-3-yl>benzaldehyde 

Downstream Products

• 92367-16-3 (S)-3-[4-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl]alanine 
• 133342-64-0 (S)-N-(9-fluorenylmethoxycarbonyl)-[4-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl]alanine 

Relevant articles and documents

Simple and versatile method for tagging phenyldiazirine photophores

The first effective method for the introduction of a versatile substituent on 3-phenyl-3-trifluoromethyldiazirine has been developed. The simple preparation of a useful aldehyde intermediate allows easy access to various elaborated photoaffinity ligands, including a l-phenylalanine analog bearing a diazirine ring (TmdPhe). The asymmetric synthesis of TmdPhe was easily accomplished in gram quantities. Site-directed incorporation of this compound into the structure of a calmodulin-binding peptide using automated peptide synthesis afforded a photoreactive peptide that was successfully used for the specific labeling of calmodulin. Copyright