87736-88-7 Usage
Description
4-[3-(TrifluoroMethyl)-3H-diazirin-3-yl]benzyl Alcohol is a photoaffinity reagent and photo-induced crosslinking reagent, characterized by its yellow oil appearance. It is a unique chemical compound that plays a significant role in various applications due to its ability to form covalent bonds with target molecules upon exposure to light.
Uses
Used in Pharmaceutical Industry:
4-[3-(TrifluoroMethyl)-3H-diazirin-3-yl]benzyl Alcohol is used as a photoaffinity reagent for the identification and characterization of biologically active molecules. Its ability to form covalent bonds with target molecules upon exposure to light allows researchers to study the structure, function, and interactions of these molecules in detail.
Used in Chemical Research:
4-[3-(TrifluoroMethyl)-3H-diazirin-3-yl]benzyl Alcohol is used as a photo-induced crosslinking reagent in chemical research to investigate the structure and function of proteins, nucleic acids, and other biomolecules. Its photoreactive properties enable the formation of covalent bonds between molecules, facilitating the study of their interactions and mechanisms of action.
Used in Biochemical Analysis:
4-[3-(TrifluoroMethyl)-3H-diazirin-3-yl]benzyl Alcohol is used as a photoaffinity probe in biochemical analysis to map the binding sites and conformational changes of biomolecules. Its photoreactive properties allow for the selective labeling and identification of specific regions within the target molecules, providing valuable insights into their structure and function.
Used in Drug Discovery:
4-[3-(TrifluoroMethyl)-3H-diazirin-3-yl]benzyl Alcohol is used as a tool in drug discovery to identify potential drug targets and develop novel therapeutic agents. Its ability to form covalent bonds with target molecules upon exposure to light enables the screening of large compound libraries for potential drug candidates and the optimization of their binding properties.
Check Digit Verification of cas no
The CAS Registry Mumber 87736-88-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,7,7,3 and 6 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 87736-88:
(7*8)+(6*7)+(5*7)+(4*3)+(3*6)+(2*8)+(1*8)=187
187 % 10 = 7
So 87736-88-7 is a valid CAS Registry Number.
87736-88-7Relevant articles and documents
Ammonia-free synthesis of 3-trifluoromethyl-3-phenyldiaziridine
Kumar, Arun Babu,Manetsch, Roman
, p. 626 - 631 (2018/02/26)
An ammonia-free synthesis of 3-trifluoromethyl-3-phenyldiaziridine, an important intermediate in the synthesis of a widely used photolabel 3-trifluoromethyl-3-phenyldiazirine, is described. By avoiding the use of volatile, corrosive, and toxic anhydrous ammonia, the major hazard involved in the synthesis of this widely used photolabel is eliminated. Furthermore, this synthesis is convenient compared to the conventional route, since it is significantly less time consuming and, due to the absence of liquid ammonia, this method does not require the maintenance of low temperature for prolonged periods.
Diazirine-containing RNA photo-cross-linking probes for capturing microRNA targets
Nakamoto, Kosuke,Ueno, Yoshihito
, p. 2463 - 2472 (2014/04/17)
Here, we report the applicability of diazirine-containing RNA photo-cross-linking probes for the identification of microRNA (miRNA) targets. The RNA cross-linking probes were synthesized by substituting the RNA nucleobases with nucleoside analogues such as 1-O-[3-(3-trifluoromethyl-3H- diazirin-3-yl)]benzyl-β-d-ribofuranose or 1-O-[4-(3-trifluoromethyl-3H- diazirin-3-yl)]benzyl-β-d-ribofuranose that carry aryl trifluoromethyl diazirine moieties. The probes were successfully cross-linked with synthetic RNAs containing the four natural nucleosides on the opposite site of the nucleoside analogues. Furthermore, it was found that miRNAs containing these analogues were effective in regulating the expression of their target genes. Thus, RNAs containing the nucleoside analogues are promising candidates as photo-cross-linking probes to identify the target mRNAs of miRNAs.
Fluorous aryldiazirine photoaffinity labeling reagents
Song, Zhiquan,Zhang, Qisheng
supporting information; experimental part, p. 4882 - 4885 (2010/01/06)
Two fluorous versions of trifluoromethyldiazirine derivatives have been designed and synthesized. The new photoaffinity labeling reagents have reactivity similar to that of their aryltrifluoromethyldiazirine parent when activated in MeOH, while the reacti
