916159-69-8Relevant articles and documents
Streamlined chemoenzymatic total synthesis of prioritized ganglioside cancer antigens
Yu, Hai,Santra, Abhishek,Li, Yanhong,McArthur, John B.,Ghosh, Tamashree,Yang, Xiaoxiao,Wang, Peng G.,Chen, Xi
, p. 4076 - 4080 (2018)
A highly efficient streamlined chemoenzymatic strategy for total synthesis of four prioritized ganglioside cancer antigens GD2, GD3, fucosyl GM1, and GM3 from commercially available lactose and phytosphingosine is demonstrated. Lactosyl sphingosine (LacβS
Ganglioside GM3 and/or analogue thereof, synthesis method and application of ganglioside GM3 and/or analogue thereof
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, (2020/06/20)
The invention relates to a method for synthesizing ganglioside GM3 and/or an analogue thereof. The method includes the following steps: (1) selecting a lactose donor represented by a general formula Iand/or an analogue thereof and selecting a sphingosine
Efficient synthesis of D-erythro-sphingosine and D-erythro-azidosphingosine from D-ribo-phytosphingosine via a cyclic sulfate intermediate
Kim, Sanghee,Lee, Sukjin,Lee, Taeho,Ko, Hyojin,Kim, Deukjoon
, p. 8661 - 8664 (2007/10/03)
The synthesis of naturally occurring D-erythro-sphingosine and synthetically useful D-erythro-2-azidosphingosine from commercially available D-ribo-phytosphingosine is described. An important feature of this synthesis is the selective transformation of the 3,4-vicinal diol of phytosphingosine into the characteristic E-allylic alcohol of sphingosine via a cyclic sulfate intermediate.