917254-89-8Relevant articles and documents
Synthesis, analytical behaviour and biological evaluation of new 4-substituted pyrrolo[1,2-a]quinoxalines as antileishmanial agents
Guillon, Jean,Forfar, Isabelle,Mamani-Matsuda, Maria,Desplat, Vanessa,Saliege, Marion,Thiolat, Denis,Massip, Stephane,Tabourier, Anais,Leger, Jean-Michel,Dufaure, Benoit,Haumont, Gilbert,Jarry, Christian,Mossalayi, Djavad
, p. 194 - 210 (2008/02/01)
An original series of 4-substituted pyrrolo[1,2-a]quinoxaline derivatives, new structural analogues of Galipea species quinoline alkaloids, was synthesized from various substituted 2-nitroanilines via multistep heterocyclizations and tested for in vitro antiparasitic activity upon Leishmania amazonensis and Leishmania infantum strains. Structure-activity relationships enlighten the importance of the 4-substituted alkenyl side chain on the pyrrolo[1,2-a]quinoxaline moiety to modulate the antileishmanial activity.