59194-26-2

Basic information

• Product Name: 5-METHOXY-2-(1H-PYRROL-1-YL)ANILINE
• Synonyms: 5-METHOXY-2-(1H-PYRROL-1-YL)ANILINE;5-Mehoxy-2-(1H-pyrrol-1-yl)aniline;1-(2-Amino-4-methoxyphenyl)-1H-pyrrole;5-methoxy-2-(1H-pyrrol-1-yl)aniline (en);5-methoxy-2-(1H-pyrrol-1-yl)aniline(SALTDATA: 1HCl 0.5H2O);5-Methoxy-2-(1H-pyrrol-1-yl)benzenaMine;5-Methoxy-2-(1H-pyrrol-1-yl)
• CAS NO: 59194-26-2
• Molecular Formula: C₁₁H₁₂N₂O
• Molecular Weight: 188.23
• Mol File: 59194-26-2.mol
• Article Data: 21

Chemical Properties

• Melting Point: 41-43°C
• Boiling Point: 345.3°C at 760 mmHg
• Flash Point: 162.6°C
• Appearance: /
• Density: 1.13g/cm³
• Vapor Pressure: 6.23E-05mmHg at 25°C
• Refractive Index: 1.58
• Storage Temp.: 2-8°C(protect from light)
• PKA: 2.05±0.11(Predicted)
• CAS DataBase Reference: 5-METHOXY-2-(1H-PYRROL-1-YL)ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHOXY-2-(1H-PYRROL-1-YL)ANILINE(59194-26-2)
• EPA Substance Registry System: 5-METHOXY-2-(1H-PYRROL-1-YL)ANILINE(59194-26-2)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 59194-26-2(Hazardous Substances Data)

Usage

General Description

5-Methoxy-2-(1H-Pyrrol-1-yl)aniline is a specialized chemical compound that belongs to the class of organic compounds known as aniline and substituted anilines. Aniline is an aromatic amine that consists of a benzene ring linked to an amine group. This particular compound has a methoxy group and a 1H-pyrrole group attached to the aniline structure. This unique chemical structure imparts specific physicochemical properties which makes it applicable in various chemical reactions and preparations. Like other organic compounds, it depends on the specific nature, concentration, and context of use to determine whether it is potentially harmful or beneficial. It doesn't appear widely prevalent in any notable applications or biological systems as per current scientific literature.

InChI:InChI=1/C11H12N2O/c1-14-9-4-5-11(10(12)8-9)13-6-2-3-7-13/h2-8H,12H2,1H3

Upstream product

• 59194-25-1 1H–1–(4–methoxy–2–nitrophenyl)pyrrole 
• 96-96-8 4-methoxy-2-nitroaniline 
• 5344-78-5 4-bromo-3-nitroanizole 
• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 16133-49-6 5-methoxy-2-nitroaniline 
• 61324-93-4 1-fluoro-nitro-4-methoxybenzene 

Downstream Products

• 160657-07-8 7-methoxy-5H-pyrrolo[1,2-a]quinoxalin-4-one 
• 936110-34-8 2-chloro-N-(5-methoxy-2-pyrrol-1-yl-phenyl)-acetamide 
• 917254-91-2 1-[2-(trans-crotonylamino)-4-methoxyphenyl]pyrrole 
• 917254-93-4 1-(2-hexanoylamino-4-methoxyphenyl)pyrrole 
• 917254-89-8 C₁₅H₁₈N₂O₂ 
• 917255-00-6 2–(1H–pyrrol–1–yl)–5–methoxyacetanilide 
• 160657-08-9 4-chloro-7-methoxypyrrolo[1,2-a]quinoxaline 
• 160656-76-8 4-[4-(4-fluorobenzyl)piperazino]-7-methoxypyrrolo[1,2-a]quinoxaline 
• 1193381-84-8 C₁₄H₁₄N₂O₂ 
• 1259380-41-0 1-(4-fluorophenyl)-7'-methoxy-5'H-spiro[piperidine-4,4'-pyrrolo[1,2-a]quinoxaline] hydrochloride 
• 1259381-02-6 benzyl 7'-methoxy-5'H-spiro[piperidine-4,4'-pyrroIo[1,2-a]quinoxaline]-1-carboxylate 
• 958707-54-5 7'-methoxy-5'H-spiro[piperidine-4,4'-pyrrolo[1,2-a]quinoxaline] 
• 1259380-59-0 1-(3,5-dimethoxybenzyl)-7'-methoxy-5'H-spiro[piperidine-4,4'-pyrrolo[1,2-a]quinoxaline] 
• 1610926-58-3 N-((7-methoxy-4-phenylpyrrolo[1,2-a]quinoxalin-5(4H)-yl)methylene)butan-1-amine 

Relevant articles and documents

Simple and green synthesis of benzimidazoles and pyrrolo[1,2-: A] quinoxalines via Mamedov heterocycle rearrangement

A method for the synthesis of coupling compounds of benzimidazoles and pyrrolo[1,2-a]quinoxalines via Mamedov Heterocycle Rearrangement is reported here. This method was conducted at room temperature and only solvent (HOAc) was required. A series of 4-(1H-benzo[d]imidazol-2-yl)pyrrolo[1,2-a]quinoxaline derivatives were obtained in moderate to good yields.

KI-Mediated One-Pot Transition-Metal-Rree Synthesis of 4-Phenylpyrrolo[1,2-a]quinoxalines

An efficient and eco-friendly method for the synthesis of pyrrolo[1,2-a]quinoxalines is presented. Compared to previous methods, this protocol is transition-metal-free and only potassium iodide is required. A series of substituted 4-phenylpyrrolo[1,2-a]quinoxalines are obtained in moderate to good yields.

Catalyst-Controlled Chemodivergent Annulation to Indolo/Pyrrolo-Fused Diazepine and Quinoxaline

Catalyst-controlled chemodivergent annulation between o-indolo anilines and diazo compounds has explored for the synthesis of indolo-fused diazepine and quinoxaline. Under the Rh(III) catalyst, reaction proceeded through the free amine assisted C2?H activation followed by amidation leading to the diazepino[1,7-a]indole in a highly selective manner. While with Ru(II) catalyst, reaction involves formation Ru?carbene complex followed by ?NH2 group insertion and cascade cyclization via metallo-ene type reaction, β-hydride elimination to furnish the indolo[1,2-a]quinoxaline as the predominating product. This strategy directs modular approach towards the construction of unique indolo-fused diazepine/quinoxaline as well as pyrrolo-fused diazepine/quinoxaline scaffolds in excellent yields. (Figure presented.).