917343-25-0

Basic information

• Product Name: 2-amino-4-fluoro-N-methylbenzamide
• Synonyms: 2-amino-4-fluoro-N-methylbenzamide
• CAS NO: 917343-25-0
• Molecular Weight: 168.171
• Mol File: 917343-25-0.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 2-amino-4-fluoro-N-methylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-4-fluoro-N-methylbenzamide(917343-25-0)
• EPA Substance Registry System: 2-amino-4-fluoro-N-methylbenzamide(917343-25-0)

Safety Data

• Hazardous Substances Data: 917343-25-0(Hazardous Substances Data)

Upstream product

• 119023-25-5 4-fluoroanthranilamide 
• 446-32-2 4-fluoroanthranilic acid 
• 74-89-5 methylamine 
• 321-50-6 7-fluoro-1H-benzo[d][1,3]oxazine-2,4-dione 
• 96-31-1 N,N'-Dimethylurea 

Downstream Products

• 1372799-99-9 2-(2-chloro-5-(trifluoromethyl)pyridin-4-ylamino)-4-fluoro-N-methylbenzamide 
• 1201935-19-4 2-[[2-[(2,5-dimethylpyrazol-3-yl)amino]-5-(trifluoromethyl)-4-pyridyl]amino]-4-fluoro-N-methyl-benzamide 
• 1201934-85-1 2-[[2-[(1,3-dimethylpyrazol-4-yl)amino]-5-(trifluoromethyl)-4-pyridyl]amino]-4-fluoro-N-methyl-benzamide 

Relevant articles and documents

Importance of fluorine in 2,3-dihydroquinazolinone and its interaction study with lysozyme

The main aim of this study is to investigate the interaction of 7-fluoro-2,2-dimethyl-2,3-dihydroquinazolin-4(1H)-one with lysozyme through various spectrophotometric studies. The graph such as Stern-Volmer plot, modified Stern Volmer plot, double logarit

2,4-DIOXO-QUINAZOLINE-6-SULFONAMIDE DERIVATIVES AS INHIBITORS OF PARG

The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated.

Two-directional approach for the rapid synthesis of 2,4-bis-aminoaryl pyridine derivatives

We have developed two different approaches in parallel to rapidly access 2,4-bis aminoaryl pyridine compounds from a common starting material. The C-4/C-2 approach uses palladium-mediated coupling reactions to sequentially functionalize C-4 and then C-2. An alternative C-2/C-4 route uses a regioselective SNAr reaction to first substitute at C-2 then subsequently at C-4 by a palladium-mediated reaction. Both approaches have been used successfully to provide a range of 2,4-bis-aminoaryl pyridine compounds.