918523-46-3

Basic information

• Product Name: benzyl 2-fluoro-3-amino-6-chlorobenzoate
• Synonyms: benzyl 2-fluoro-3-amino-6-chlorobenzoate
• CAS NO: 918523-46-3
• Molecular Weight: 279.698
• Mol File: 918523-46-3.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: benzyl 2-fluoro-3-amino-6-chlorobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 2-fluoro-3-amino-6-chlorobenzoate(918523-46-3)
• EPA Substance Registry System: benzyl 2-fluoro-3-amino-6-chlorobenzoate(918523-46-3)

Safety Data

• Hazardous Substances Data: 918523-46-3(Hazardous Substances Data)

Upstream product

• 57946-56-2 2-fluoro-4-chloroaniline 
• 501-53-1 benzyl chloroformate 
• 13528-93-3 1,2-bis-(chlorodimethylsilyl)ethane 

Downstream Products

• 1186194-02-4 benzyl 6-chloro-2-fluoro-3-(N-(propylsulfonyl)propylsulfonamido)benzoate 
• 918523-76-9 2-fluoro-3-(propane-1-sulfonylamino)-benzoic acid methyl ester 
• 918523-77-0 propane-1-sulfonic acid (2-fluoro-3-hydroxymethyl-phenyl)-amide 
• 918523-78-1 propane-1-sulfonic acid (2-fluoro-3-formyl-phenyl)-amide 
• 1186609-60-8 6-chloro-2-fluoro-N-(3-methoxy-1-(4-methoxybenzyl)-1H-pyrazolo [3,4-b]pyridin-5-yl)-3-(3-(4-methoxyphenoxy)propylsulfonamido)benzamide 
• 1186609-61-9 6-chloro-2-fluoro-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-3-(3-(4-methoxyphenoxy)propylsulfonamido)benzamide 
• 1186609-66-4 6-chloro-2-fluoro-N-(3-methoxy-1-(4-methoxybenzyl)-1H-pyrazolo [3,4-b]pyridin-5-yl)-3-(propylsulfonamido)benzamide 
• 1186609-40-4 tert-butyl 5-(6-chloro-2-fluoro-3-(propylsulfonamido)benzamido)-3-ethoxy-1H-pyrazolo[3,4-b]pyridine-1-carboxylate 
• 1186607-74-8 6-chloro-2-fluoro-3-(3-hydroxypropylsulfonamido)-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)benzamide 
• 1186607-63-5 6-chloro-N-(3-ethoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-2-fluoro-3-(propylsulfonamido)benzamide 
• 1186607-42-0 6-chloro-2-fluoro-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-3-(propylsulfonamido)benzamide 
• 1186607-83-9 6-chloro-2-fluoro-3-(propylsulfonamido)-N-(1H-pyrazolo[3,4-b]pyridin-5-yl)benzamide 
• 1186609-59-5 6-chloro-2-fluoro-3-(3-(4-methoxyphenoxy)propylsulfonamido)benzoic acid 
• 1396310-77-2 N-(4-chloro-2-fluoro-3-(3-methyl-4-oxo-3,4-dihydroquinazolin-6-ylamino)phenyl)pyrrolidine-1-sulfonamide 

Relevant articles and documents

COMPOUNDS FOR THE TREATMENT OF BRAF-ASSOCIATED DISEASES AND DISORDERS

Provided herein are compounds of the Formula I: and pharmaceutically acceptable salts, solvates and polymorphs thereof, wherein L, X1, R1, R2, R3, R4, R5 and R6 are as defined herein, for the treatment of BRAF-associated diseases and disorders, including BRAF-associated tumors, including malignant and benign BRAF-associated tumors of the CNS and malignant extracranial BRAF-associated tumors.

KINASE MODULATING COMPOUNDS, COMPOSITIONS CONTAINING THE SAME AND USE THEREOF

The invention provides a compound represented by formula (I) which may modulate a kinase, and a pharmaceutical composition thereof, as well as the method for preventing or treating a protein kinase mediated disease or condition.

HETEROCYCLIC SULFONAMIDES AS RAF INHIBITORS

Compounds of Formula (I) are useful for inhibition of Raf kinases. Methods of using compounds of Formula (I), stereoisomers, tautomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.