919486-28-5

Basic information

• Product Name: 5-Pyrimidinecarboxamide, N-methyl-2-(methylsulfonyl)-4-[(phenylmethyl)amino]-
• CAS NO: 919486-28-5
• Molecular Formula: C14H16N4O3S
• Molecular Weight: 320.372
• Mol File: 919486-28-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-Pyrimidinecarboxamide, N-methyl-2-(methylsulfonyl)-4-[(phenylmethyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Pyrimidinecarboxamide, N-methyl-2-(methylsulfonyl)-4-[(phenylmethyl)amino]-(919486-28-5)
• EPA Substance Registry System: 5-Pyrimidinecarboxamide, N-methyl-2-(methylsulfonyl)-4-[(phenylmethyl)amino]-(919486-28-5)

Safety Data

• Hazardous Substances Data: 919486-28-5(Hazardous Substances Data)

Upstream product

• 919486-27-4 4-(benzylamino)-N-methyl-2-(methylsulfanyl)pyrimidine-5-carboxamide 
• 686267-34-5 4-(benzylamino)-2-(methylsulfanyl)pyrimidine-5-carboxylic acid 
• 5909-24-0 4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester 
• 100973-67-9 ethyl 4-(benzylamino)-2-(methylthio)pyrimidine-5-carboxylate 
• 100-46-9 benzylamine 

Relevant articles and documents

Synthesis and evaluation of 2-{[2-(4-hydroxyphenyl)-ethyl]amino}pyrimidine-5-carboxamide derivatives as novel STAT6 inhibitors

The STAT6 (signal transducers and activators of transcription 6) protein is activated by interleukin (IL)-4 and IL-13, and plays an important role in T-helper cell 2 (Th2) differentiation. STAT6 might therefore be an excellent therapeutic target for various allergic conditions, including asthma and atopic diseases. We synthesized a series of 2-{[2-(4-hydroxyphenyl)ethyl]amino}pyrimidine-5-carboxamide derivatives and evaluated their STAT6 inhibitory activities. Among these compounds, 4-(benzylamino)-2-{[2-(3-chloro-4-hydroxyphenyl)ethyl]amino}pyrimidine-5-carboxamide (2t, AS1517499) showed potent STAT6 inhibition with an IC50 value of 21 nM, and also inhibited IL-4-induced Th2 differentiation of mouse spleen T cells with an IC50 value of 2.3 nM and without influencing T-helper cell 1 (Th1) differentiation induced by IL-12.