923243-45-2

Basic information

• Product Name: N-(4-fluorophenyl)-6-hydroxynicotinamide
• Synonyms: N-(4-fluorophenyl)-6-hydroxynicotinamide
• CAS NO: 923243-45-2
• Molecular Weight: 232.214
• Mol File: 923243-45-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(4-fluorophenyl)-6-hydroxynicotinamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-fluorophenyl)-6-hydroxynicotinamide(923243-45-2)
• EPA Substance Registry System: N-(4-fluorophenyl)-6-hydroxynicotinamide(923243-45-2)

Safety Data

• Hazardous Substances Data: 923243-45-2(Hazardous Substances Data)

Upstream product

• 5006-66-6 6-hydroxy-3-pyridinecarboxylic acid 
• 57659-03-7 2-hydroxy-5-pyridinecarboxylic acid chloride 
• 371-40-4 4-fluoroaniline 

Relevant articles and documents

Boronic acid-containing aminopyridine- and aminopyrimidinecarboxamide CXCR1/2 antagonists: Optimization of aqueous solubility and oral bioavailability

Abstract The chemokine receptors CXCR1 and CXCR2 are important pharmaceutical targets due to their key roles in inflammatory diseases and cancer progression. We have previously identified 2-[5-(4-fluoro-phenylcarbamoyl)-pyridin-2-ylsulfanylmethyl]-phenylboronic acid (SX-517) and 6-(2-boronic acid-5-trifluoromethoxy-benzylsulfanyl)-N-(4-fluoro-phenyl)-nicotinamide (SX-576) as potent non-competitive boronic acid-containing CXCR1/2 antagonists. Herein we report the synthesis and evaluation of aminopyridine and aminopyrimidine analogs of SX-517 and SX-576, identifying (2-{(benzyl)[(5-boronic acid-2-pyridyl)methyl]amino}-5-pyrimidinyl)(4-fluorophenylamino)formaldehyde as a potent chemokine antagonist with improved aqueous solubility and oral bioavailability.