923590-95-8 Usage
Description
4-BROMO-ISOINDOLINE HCL, also known as 4-Bromoisoindoline Hydrochloride, is a chemical compound that belongs to the isoindoline family. It is characterized by the presence of a bromine atom at the 4-position and a hydrochloride group, which gives it unique chemical properties and potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
4-BROMO-ISOINDOLINE HCL is used as a precursor in the synthesis of isoindolines, which are known as histone deacetylase (HDAC) inhibitors. These HDAC inhibitors have gained significant attention in the pharmaceutical industry due to their potential role in the treatment of various diseases, including cancer, neurological disorders, and cardiovascular diseases.
As HDAC inhibitors, isoindolines can modulate gene expression by altering the acetylation state of histone proteins, leading to changes in chromatin structure and accessibility of DNA to transcription factors. This, in turn, can result in the regulation of various cellular processes, such as cell cycle progression, differentiation, and apoptosis.
Furthermore, 4-BROMO-ISOINDOLINE HCL can also be utilized in the development of novel drug candidates with improved pharmacological properties, such as enhanced potency, selectivity, and reduced side effects. This can be achieved through the optimization of the chemical structure and the exploration of new synthetic routes to obtain more effective and safer isoindoline-based HDAC inhibitors.
Check Digit Verification of cas no
The CAS Registry Mumber 923590-95-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,2,3,5,9 and 0 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 923590-95:
(8*9)+(7*2)+(6*3)+(5*5)+(4*9)+(3*0)+(2*9)+(1*5)=188
188 % 10 = 8
So 923590-95-8 is a valid CAS Registry Number.
923590-95-8Relevant articles and documents
INHIBITORS OF MLH1 AND/OR PMS2 FOR CANCER TREATMENT
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Paragraph 00393-00394, (2021/12/28)
The present invention relates to compounds of Formula (I) that target the MLH1 and/or PMS2 proteins that are components of the DNA Mismatch Repair (MMR) process: Formula (I) wherein R1, R2, R3, R4, R6
PROCESS AND INTERMEDIATES FOR PREPARING MACROLACTAMS
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Paragraph 0254-0257, (2013/10/22)
The present invention relates to macrolactam compounds, intermediates useful in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing and modifying macrolactams. One use of the compounds and methods described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. An example of an HCV inhibitory compound that can be synthesized using the procedures described herein is Compound A and derivative thereof.
Synthesis of vaniprevir (MK-7009): Lactamization to prepare a 22-membered macrocycle
Song, Zhiguo J.,Tellers, David M.,Journet, Michel,Kuethe, Jeffrey T.,Lieberman, David,Humphrey, Guy,Zhang, Fei,Peng, Zhihui,Waters, Marjorie S.,Zewge, Daniel,Nolting, Andrew,Zhao, Dalian,Reamer, Robert A.,Dormer, Peter G.,Belyk, Kevin M.,Davies, Ian W.,Devine, Paul N.,Tschaen, David M.
, p. 7804 - 7815 (2011/12/14)
Development of a practical synthesis of MK-7009, a 22-membered macrocycle, is described. A variety of ring-closing strategies were evaluated, including ring-closing metathesis, intermolecular palladium-catalyzed cross-couplings, and macrolactamization. Ri
