924892-68-2

Basic information

• Product Name: N-benzyl-6-chloro-N'-(4-fluorophenyl)-1,3,5-triazine-2,4-diamine
• Synonyms: N-benzyl-6-chloro-N'-(4-fluorophenyl)-1,3,5-triazine-2,4-diamine
• CAS NO: 924892-68-2
• Molecular Weight: 329.764
• Mol File: 924892-68-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-benzyl-6-chloro-N'-(4-fluorophenyl)-1,3,5-triazine-2,4-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-6-chloro-N'-(4-fluorophenyl)-1,3,5-triazine-2,4-diamine(924892-68-2)
• EPA Substance Registry System: N-benzyl-6-chloro-N'-(4-fluorophenyl)-1,3,5-triazine-2,4-diamine(924892-68-2)

Safety Data

• Hazardous Substances Data: 924892-68-2(Hazardous Substances Data)

Upstream product

• 371-40-4 4-fluoroaniline 
• 100-46-9 benzylamine 
• 131468-33-2 (4,6-dichloro-[1,3,5]triazin-2-yl)-(4-fluorophenyl)-amine 

Relevant articles and documents

Synthesis and antitumor evaluation of a novel series of triaminotriazine derivatives

A series of triaminotriazine derivatives (compounds 5a-f, 6a-x, and 7a-g) was designed, synthesized, and evaluated for their inhibition activities to colorectal cancer (CRC) cell lines (HCT-116 and HT-29). Most of the synthesized compounds demonstrated moderate anti-proliferatory effects on both HCT-116 and HT-29 cell lines at the concentration of 10 μM. The inhibitory activities against HCT-116 and HT-29 cell lines were discussed to develop the structure-activity relationships of this new series. Compounds 6l and 6o exhibited prominent inhibition activities toward HCT-116, with IC50s of 0.76 and 0.92 μM, respectively. The in vivo antitumor studies and pharmacokinetics of compound 6l showed that it might be a promising new hit for further development of antitumor agents.