928152-86-7

Basic information

• Product Name: 5-Pyrimidinecarboxylic acid, 4-methyl-6-(4-methylphenyl)-2-(1-piperidinyl)-, ethyl ester
• CAS NO: 928152-86-7
• Molecular Formula: C20H25N3O2
• Molecular Weight: 339.437
• Mol File: 928152-86-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 5-Pyrimidinecarboxylic acid, 4-methyl-6-(4-methylphenyl)-2-(1-piperidinyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Pyrimidinecarboxylic acid, 4-methyl-6-(4-methylphenyl)-2-(1-piperidinyl)-, ethyl ester(928152-86-7)
• EPA Substance Registry System: 5-Pyrimidinecarboxylic acid, 4-methyl-6-(4-methylphenyl)-2-(1-piperidinyl)-, ethyl ester(928152-86-7)

Safety Data

• Hazardous Substances Data: 928152-86-7(Hazardous Substances Data)

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 110-89-4 piperidine 
• 1078156-79-2 ethyl 1,2-dihydro-6-methyl-2-oxo-4-(4-methylphenyl)pyrimidine-5-carboxylate 
• 141-97-9 ethyl acetoacetate 
• 299949-24-9 ethyl 6-methyl-2-oxo-4-p-tolyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1078156-79-2 C₁₅H₁₆N₂O₃ 
• 185023-34-1 5-carboethoxy-6-methyl-4-(4-methylphenyl)-1H-pyrimidin-2-thione 

Downstream Products

• 1265402-25-2 (4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)methanol 
• 1265402-31-0 4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidine-5-carbaldehyde 
• 1265402-37-6 2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)-2-(trimethylsilyloxy)acetonitrile 
• 1265402-43-4 methyl 2-hydroxy-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)acetate 
• 1265402-49-0 methyl 2-tert-butoxy-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)acetate 
• 1265402-55-8 2-tert-butoxy-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)acetic acid 

Relevant articles and documents

Copper(i) chloride promoted Csp2-N cross-coupling of 1,2-di(pyrimidin-2-yl) disulfides with amines: An efficient approach to obtain C2-amino functionalized pyrimidines

The copper(i)-promoted cross-coupling of 1,2-di(pyrimidin-2-yl) disulfides with aromatic amines and aliphatic amines to deliver C-N coupling products in moderate to good yields is reported in this paper. Central to this strategy is the conversion of disulfides into aryl- and alkyl amines by a copper-promoted chemoselective C-S bond cleavage.

Molecular iodine-mediated S-N and C-N cross-coupling and oxidative aromatization of 3,4-dihydropyrimidin-2(1H)-thiones with secondary amines

A domino S-N and C-N coupling/oxidative aromatization process to synthesize 2-aminothio-phenylpyrimidines and 2-amino-phenylpyrimidines by S-N and C-N cross-coupling reactions is described. This methodology couples 3,4-dihydropyrimidine-2-thiones and secondary amines catalyzed by molecular iodine. Remarkably the C-N coupled product was obtained via a desulfitative coupling-aromatization reaction in one-pot reaction.

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