931386-09-3

Basic information

• Product Name: N⁴-benzoyl-2'-O-(tert-butyldithiomethyl)cytidine
• Synonyms: N⁴-benzoyl-2'-O-(tert-butyldithiomethyl)cytidine
• CAS NO: 931386-09-3
• Molecular Weight: 481.594
• Mol File: 931386-09-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N⁴-benzoyl-2'-O-(tert-butyldithiomethyl)cytidine(CAS DataBase Reference)
• NIST Chemistry Reference: N⁴-benzoyl-2'-O-(tert-butyldithiomethyl)cytidine(931386-09-3)
• EPA Substance Registry System: N⁴-benzoyl-2'-O-(tert-butyldithiomethyl)cytidine(931386-09-3)

Safety Data

• Hazardous Substances Data: 931386-09-3(Hazardous Substances Data)

Upstream product

• 139434-68-7 N-benzoyl-3′,5′-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2′-O-[(methylthio)methyl]cytidine 
• 4546-55-8 N-benzoyladenosine 
• 79154-57-7 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-N₆-benzoyladenosine 
• 75-66-1 2-methylpropan-2-thiol 

Relevant articles and documents

Synthesis of RNA using 2′-O-DTM protection

tert-Butyldithiomethyl (DTM), a novel hydroxyl protecting group, cleavable under reductive conditions, was developed and applied for the protection of 2′-OH during solid-phase RNA synthesis. This function is compatible with all standard protecting groups used in oligonucleotide synthesis, and allows for fast and high-yield synthesis of RNA. Oligonucleotides containing the 2′-O-DTM groups can be easily deprotected under the mildest possible aqueous and homogeneous conditions. The preserved 5′-O-DMTr function can be used for high-throughput cartridge RNA purification. Copyright