93246-58-3

Basic information

• Product Name: Benzamide, 2-amino-5-(4-morpholinyl)-
• CAS NO: 93246-58-3
• Molecular Formula: C11H15N3O2
• Molecular Weight: 221.259
• Mol File: 93246-58-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzamide, 2-amino-5-(4-morpholinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 2-amino-5-(4-morpholinyl)-(93246-58-3)
• EPA Substance Registry System: Benzamide, 2-amino-5-(4-morpholinyl)-(93246-58-3)

Safety Data

• Hazardous Substances Data: 93246-58-3(Hazardous Substances Data)

Upstream product

• 77206-97-4 2-nitro-5-fluorobenzamide 
• 394-02-5 5-fluoro-2-nitrobenzoyl chloride 
• 320-98-9 5-fluoro-2-nitrobenzoic acid 
• 455-38-9 3-fluorobenzoic acid 
• 733806-19-4 5-morpholino-2-nitrobenzonitrile 
• 41994-44-9 5-chloro-2-nitrobenzoyl chloride 
• 2516-95-2 5-chloro-2-nitrobenzoic acid 
• 40763-96-0 2-nitro-5-chlorobenzamide 
• 404009-38-7 2-nitro-5-(1-morpholino)-benzamide 

Downstream Products

• 733806-36-5 6-methylpyridine-2-carboxylic acid (2-carbamoyl-4-(morpholin-1-yl)phenyl)amide 
• 1253732-02-3 2-{4-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-3,5-dimethyl-phenyl}-6-morpholin-4-yl-3H-quinazolin-4-one 

Relevant articles and documents

2-((3,5-Dinitrobenzyl)thio)quinazolinones: Potent Antimycobacterial Agents Activated by Deazaflavin (F420)-Dependent Nitroreductase (Ddn)

Swapping the substituents in positions 2 and 4 of the previously synthesized but yet undisclosed 5-cyano-4-(methylthio)-2-arylpyrimidin-6-ones 4, ring closure, and further optimization led to the identification of the potent antitubercular 2-thio-substituted quinazolinone 26. Structure-activity relationship (SAR) studies indicated a crucial role for both meta-nitro substituents for antitubercular activity, while the introduction of polar substituents on the quinazolinone core allowed reduction of bovine serum albumin (BSA) binding (63c, 63d). While most of the tested quinazolinones exhibited no cytotoxicity against MRC-5, the most potent compound 26 was found to be mutagenic via the Ames test. This analogue exhibited moderate inhibitory potency against Mycobacterium tuberculosis thymidylate kinase, the target of the 3-cyanopyridones that lies at the basis of the current analogues, indicating that the whole-cell antimycobacterial activity of the present S-substituted thioquinazolinones is likely due to modulation of alternative or additional targets. Diminished antimycobacterial activity was observed against mutants affected in cofactor F420 biosynthesis (fbiC), cofactor reduction (fgd), or deazaflavin-dependent nitroreductase activity (rv3547), indicating that reductive activation of the 3,5-dinitrobenzyl analogues is key to antimycobacterial activity.

Molecular modelling, synthesis, cytotoxicity and anti-tumour mechanisms of 2-aryl-6-substituted quinazolinones as dual-targeted anti-cancer agents

Background and Purpose Our previous study demonstrated that 6-(pyrrolidin-1-yl)-2-(3-methoxyphenyl)quinazolin-4-one (HMJ38) was a potent anti-tubulin agent. Here, HMJ38 was used as a lead compound to develop more potent anti-cancer agents and to examine t

CONDENSED PYRIDINES AND PYRIMIDINES AND THEIR USE AS ALK-5 RECEPTOR LIGANDS

Therapeutically active substituted quinoline and quinazoline compounds derivatives of formula (I) wherein X is N or CH, Y is NH, N (alkyl) or NH-CH2, and R2 and R3 are specified heterorings, the use thereof in therapy, particularly in the treatment or prophylaxis of disorders characterised by overexpression of transforming growth factor β (TGF-β), and pharmaceutical compositions for use in such therapy are disclosed.