93472-50-5

Basic information

• Product Name: Isoquinoline, 1-methyl-3,4-diphenyl-
• CAS NO: 93472-50-5
• Molecular Formula: C22H17N
• Molecular Weight: 295.384
• Mol File: 93472-50-5.mol
• Article Data: 46

Chemical Properties

• CAS DataBase Reference: Isoquinoline, 1-methyl-3,4-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Isoquinoline, 1-methyl-3,4-diphenyl-(93472-50-5)
• EPA Substance Registry System: Isoquinoline, 1-methyl-3,4-diphenyl-(93472-50-5)

Safety Data

• Hazardous Substances Data: 93472-50-5(Hazardous Substances Data)

Upstream product

• 24108-37-0 3-methyl-5,6-diphenyl-1,2,4-triazine 
• 118-92-3 anthranilic acid 
• 1257846-52-8 (E)-1-(2-((E)-1,2-diphenylvinyl)phenyl)ethanone oxime 
• 1293990-84-7 (E)-1-phenylethan-1-one O-pivaloyl oxime 
• 501-65-5 diphenyl acetylene 
• 98-86-2 acetophenone 
• 19433-17-1 acetophenone O-acetyloxime 
• 26060-56-0 (1-phenylethylidene)(benzoyloxy)amine 
• 156605-56-0 1-phenylethan-1-one O-pivaloyl oxime 
• 52260-22-7 N-chloro-1-phenylethan-1-imine 
• 10341-75-0 (E)-1-phenylethanone oxime 
• 63563-93-9 (E)-2-(((1-phenylethylidene)amino)oxy)acetic acid 
• 4545-21-5 acetophenone p-toluenesulfonylhydrazone 
• 2909-32-2 pyridine-2-carboxylic acid (1-phenyl-ethyl)amide 

Downstream Products

• 585531-26-6 1-bromomethyl-3,4-diphenylisoquinoline 
• 1257846-42-6 (E)-3,4-diphenyl-1-styrylisoquinoline 

Relevant articles and documents

Rhodium-Catalyzed One-Pot Access to N-Polycyclic Aromatic Hydrocarbons from Aryl Ketones through Triple C-H Bond Activations

A Rh-catalyzed pot and step economic synthesis of aza-polycyclic aromatic hydrocarbons (N-PAHs) from readily available aryl ketones and alkynes has been disclosed. Additionally, a novel synthetic application of the well-known aminating reagent hydroxylamine-O-sulfonic acid (HOSA) has been explored as an in situ redox-neutral directing group for the formation of N-PAHs via isoquinoline. Multiple bond formation in a single operation through a cascade of triple C-H bond activations is the beauty of this protocol. The challenging annulations of two different alkynes in a regioselective fashion have been demonstrated effectively. Mechanistic studies reveal that 3,4-diphenyl-1-methylisoquinoline is an active intermediate for this one-pot transformation.

Ruthenaelectro-Catalyzed Domino Three-Component Alkyne Annulation for Expedient Isoquinoline Assembly

The electrochemical three-component assembly of isoquinolines has been accomplished by ruthenaelectro-catalyzed C?H/N?H functionalization. The robustness of the electrocatalysis was reflected by an ample substrate scope, an efficient electrooxidation, and an operationally friendly procedure. The isolation of key intermediates and detailed mechanistic studies, including unprecedented cyclovoltammetric analysis of a seven-membered ruthenacycle, provided support for an unusual ruthenium(II/III/I) regime.

Rh(III)-catalyzed synthesis of isoquinolines using the N-Cl bond of N-chloroimines as an internal oxidant

The Rh(III)-catalyzed coupling of N-chloroimines with alkynes for the efficient synthesis of isoquinolines is reported. This represents the first use of the N-Cl bond of N-chloroimines as an internal oxidant for construction of the isoquinoline skeleton. The synthesis features atom and step economy, a green solvent (EtOH), mild reaction conditions, and a broad substrate scope.