2909-32-2

Basic information

• Product Name: pyridine-2-carboxylic acid (1-phenyl-ethyl)amide
• Synonyms: pyridine-2-carboxylic acid (1-phenyl-ethyl)amide
• CAS NO: 2909-32-2
• Molecular Weight: 226.278
• Mol File: 2909-32-2.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: pyridine-2-carboxylic acid (1-phenyl-ethyl)amide(CAS DataBase Reference)
• NIST Chemistry Reference: pyridine-2-carboxylic acid (1-phenyl-ethyl)amide(2909-32-2)
• EPA Substance Registry System: pyridine-2-carboxylic acid (1-phenyl-ethyl)amide(2909-32-2)

Safety Data

• Hazardous Substances Data: 2909-32-2(Hazardous Substances Data)

Upstream product

• 492-73-9 2,2'-Pyridil 
• 618-36-0 rac-methylbenzylamine 
• 39901-94-5 2-picolinoyl chloride hydrochloride 
• 69157-32-0 picolinic acid 
• 98-98-6 2-Picolinic acid 
• 50919-07-8 1-(3-methoxy-phenyl)-ethylamine 
• 541-41-3 chloroformic acid ethyl ester 
• 100-70-9 2-Cyanopyridine 
• 98-85-1 1-Phenylethanol 
• 100-46-9 benzylamine 
• 18904-38-6 N-benzyl-2-pyridinecarboxamide 

Downstream Products

• 1404616-90-5 N-(1-(3-methoxy-6-(n-butylthio)phenyl)-1-methylethyl)picolinamide 
• 1404616-91-6 N-(1-(3-methoxy-2,6-di(n-butylthio)phenyl)-1-methylethyl)picolinamide 
• 1721-96-6 1-methyl-3-phenylisoquinoline 
• 93472-50-5 1-methyl-3,4-diphenylisoquinoline 
• 22875-84-9 2,3-diphenyl-1-butene 

Relevant articles and documents

Tropylium-promoted Ritter reactions

The Ritter reaction used to be one of the most powerful synthetic tools to functionalize alcohols and nitriles, providing valuableN-alkyl amide products. However, this reaction has not been frequently used in modern organic synthesis due to its employment of strongly acidic and harsh reaction conditions, which often lead to complicated side reactions. Herein, we report the development of a new method using salts of the tropylium ion to promote the Ritter reaction. This method works well on a range of alcohol and nitrile substrates, giving the corresponding products in good to excellent yields. This reaction protocol is amenable to microwave and continuous flow reactors, offering an attractive opportunity for further applications in organic synthesis.

Cobalt-Catalyzed, Directed C-H Functionalization/Annulation of Phenylglycinol Derivatives with Alkynes

A new method for cobalt-catalyzed C(sp2)-H functionalization of phenylglycinol derivatives with terminal and internal alkynes directed by picolinamide auxiliary has been developed. This method offers an efficient and highly regioselective route for the synthesis of 1-hydroxymethyltetrahydroisoquinolines. The reaction employs commercially available Co(II) catalyst in the presence of Mn(III) cooxidant and oxygen as a terminal oxidant and proceeds with full preservation of original stereochemistry.

Highly chemoselective, sterically sensitive NHC-catalysed amine acylation with pyridil

A new strategy for the protection of amines has been developed involving reaction with pyridil under the influence of N-heterocyclic carbene catalysis. The methodology is capable of distinguishing between two amines characterised by small differences in steric bulk and the resulting pyridoyl amides can be cleaved without requiring either strongly acidic or basic hydrolysis.