935-69-3

Basic information

• Product Name: 7-METHYLADENINE
• Synonyms: 6-AMINO-7-METHYLPURINE;7-METHYLADENINE;7-METHYL-7H-PURIN-6-AMINE;Adenine, 7-methyl-;N7-Methyladenine;7-Methyladenine90%;7H-Purin-6-amine, 7-methyl- (9CI);7-Methyladenine, HPLC 90%
• CAS NO: 935-69-3
• Molecular Formula: C₆H₇N₅
• Molecular Weight: 149.15
• Product Categories: PYRIMIDINE;Nucleic acids
• Mol File: 935-69-3.mol
• Article Data: 13

Chemical Properties

• Melting Point: 323 °C
• Boiling Point: 260.22°C (rough estimate)
• Flash Point: 187.2°C
• Appearance: White to off-white/Powder
• Density: 1.1798 (rough estimate)
• Vapor Pressure: 3.67E-06mmHg at 25°C
• Refractive Index: 1.8070 (estimate)
• PKA: 4.73±0.30(Predicted)
• CAS DataBase Reference: 7-METHYLADENINE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-METHYLADENINE(935-69-3)
• EPA Substance Registry System: 7-METHYLADENINE(935-69-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22-43-36
• Safety Statements: 24/25-36/37-26
• WGK Germany: 3
• Hazardous Substances Data: 935-69-3(Hazardous Substances Data)

Usage

Description

7-METHYLADENINE, also known as 7-Methyladenine, is an organic compound with the chemical formula C10H13N5. It is an adenine derivative, where a methyl group is attached to the nitrogen atom at the 7th position. 7-METHYLADENINE is characterized by its white to almost white powder appearance.

Uses

Used in Pharmaceutical Industry:
7-METHYLADENINE is used as an active pharmaceutical ingredient for the development of drugs targeting various diseases. Its unique chemical structure allows it to interact with specific biological targets, making it a promising candidate for drug discovery and development.
Used in Research and Development:
7-METHYLADENINE is utilized as a research compound in the field of biochemistry and molecular biology. It serves as a valuable tool for studying the structure, function, and interactions of nucleic acids and their derivatives.
Used in Chemical Synthesis:
7-METHYLADENINE is employed as a key intermediate in the synthesis of various complex organic molecules and pharmaceuticals. Its unique chemical properties enable it to be a versatile building block for the development of novel compounds with potential applications in various industries.

InChI:InChI=1/C6H7N5/c1-11-3-10-6-4(11)5(7)8-2-9-6/h2-3H,1H3,(H2,7,8,9)

Upstream product

• 40637-80-7 4-amino-5-cyano-1-methyl-1H-imidazole 
• 77287-34-4 formamide 
• 3324-79-6 7-Methyl-6-thiopurin 
• 5440-17-5 6-chloro-7-methyl-7H-purine 
• 117343-06-3 7-methyl-3-oxy-7H-purin-6-ylamine 
• 1774-47-6 trimethylsulfoxonium iodide 
• 81980-38-3 Carbamic acid (R)-2,7-diamino-1-[9-(4-hydroxy-5-phosphonooxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamino]-6-methyl-5,8-dioxo-2,3,5,8-tetrahydro-1H-pyrrolo[1,2-a]indol-9-ylmethyl ester 
• 81319-59-7 7-Methyladenosine Perchlorate 
• 73-24-5 7H-purin-6-ylamine 
• 74-88-4 methyl iodide 
• 96695-53-3 N⁶-benzoyl-7-methyladenine 
• 81619-09-2 3-pivaloyloxymethyladenine 
• 52376-64-4 N⁶-methoxy-7-methyladenine 
• 191416-90-7 4-formamido-N'-methoxy-1-methyl-1H-imidazole-5-carboxamidine 

Downstream Products

• 5155-12-4 4-amino-N-(7-methyl-7H-purin-6-yl)-benzenesulfonamide 

Relevant articles and documents

Peptide deformylase inhibitors

The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhibition of bacterial peptide deformylase (PDF) activity.

8-(2-Furyl)adenine derivatives as A2A adenosine receptor ligands

Selective adenosine receptor modulators are potential tools for numerous therapeutic applications, including cardiovascular, inflammatory, and neurodegenerative diseases. In this work, the synthesis and biological evaluation at the four human adenosine receptor subtypes of a series of 9-substituted 8-(2-furyl)adenine derivatives are reported. Results show that 8-(2-furyl)-9-methyladenine is endowed with high affinity at the A2A subtype. Further modification of this compound with introduction of arylacetyl or arylcarbamoyl groups in N6-position takes to different effects on the A2A affinity and in particular on the selectivity versus the other three adenosine receptor subtypes. A molecular modelling analysis at three different A2A receptor crystal structures provides an interpretation of the obtained biological results.

Purines. LXXV. Dimroth rearrangement, hydrolytic deamination, and pyrimidine-ring breakdown of 7-alkylated 1-alkoxyadenines: N(1)-C(2) versus N(1)-C(6) bond fission

On treatment with boiling H2O for 5-6h, 1-alkoxy-7-alkyladenines (13) underwent hydrolytic cleavage of the N(1)-C(2) and the N(1)-C(6) bonds to produce the imidazole-5-carboxamidines (14) in 53-60% yields and the imidazole-5-carboxamides (18) i