93743-65-8Relevant articles and documents
Nickel-catalyzed C-F/O-H [4+2] Annulation of ortho-Fluoro Aromatic Carboxylic Acids with Alkynes
Chatani, Naoto,Matsuura, Akihisa
supporting information, p. 1990 - 1992 (2022/01/12)
Synthesis of 1H-isochromen-1-one derivatives through the C-F/O-H annulation of ortho-fluoro-substituted benzoic acids and alkynes catalyzed by a nickel complex is reported. The reaction involves the chelation-assisted activation of C-F bonds. The addition of a base, Mg(OtBu)2 is crucial for the reaction to proceed successfully.
Ruthenium(ii)-catalyzed electrooxidative [4+2] annulation of benzylic alcohols with internal alkynes: Entry to isocoumarins
Luo, Mu-Jia,Hu, Ming,Song, Ren-Jie,He, De-Liang,Li, Jin-Heng
supporting information, p. 1124 - 1127 (2019/01/28)
A new ruthenium(ii)-catalyzed electrooxidative [4+2] annulation of primary benzylic alcohols with internal alkynes is described, which enables benzylic alcohols as weakly directing group precursors to access isocoumarins via multiple C-H functionalization. The reaction works well with a broad substrate scope, tolerates a wide range of functional groups, and incorporates practically the isocoumarin unit into diverse bioactive molecules. Mechanistic studies indicate that activation of aryl C(sp2)-H bonds is achieved through the generation of the active benzoyloxy-Ru(ii) intermediates via oxidation of benzylic alcohols using an electrooxidative Ru(ii) catalyst.
Electrooxidative Ruthenium-Catalyzed C?H/O?H Annulation by Weak O-Coordination
Qiu, Youai,Tian, Cong,Massignan, Leonardo,Rogge, Torben,Ackermann, Lutz
supporting information, p. 5818 - 5822 (2018/05/14)
Electrocatalysis has been identified as a powerful strategy for organometallic catalysis, and yet electrocatalytic C?H activation is restricted to strongly N-coordinating directing groups. The first example of electrocatalytic C?H activation by weak O-coo
