93913-62-3Relevant articles and documents
A novel asymmetric total synthesis of (+)-artemisinin
Constantino, Mauricio Gomes,Beltrame Jr., Milton,De Silva, Gil Valdo Jose,Zukerrnan-Schpector, Julio
, p. 321 - 329 (1996)
A 12-step synthesis of the natural product (+)-Artemisinin, very active against malaria, is described. (-)-Isopulegol, which already contains two of the asymmetric centers of (+)-Artemisinin in the correct absolute configuration, was used as starting material.
TOTAL SYNTHESIS OF ARTEANNUIN AND DEOXYARTEANNUIN
Xu Xing-Xiang,Zhu Jie,Huang Da-Zhong,Zhou Wei-Shan
, p. 819 - 828 (2007/10/02)
Arteannuin 1 is a new sesquiterpene lactone containing a peroxide linkage and is an antimalarial principle isolated from Artemisia annua L. .R(+)-Citronellal 5 as a starting material for the total synthesis was converted into 11R(-)-methyl dihydroarteannuinate 12 in 14 steps.The key intermediate 4 was obtained from compound 12 in 5 steps.The introduction of hydroperoxide in 4 by photooxidation followed by acid treatment gave 1.Hydroxylation of 4 with osmium tetraoxide afforded deoxyarteannuin 2.