942-32-5

Basic information

• Product Name: 3-methyl-1-phenyl-1H-pyrazol-5-ol
• Synonyms: 3-methyl-1-phenyl-1H-pyrazol-5-ol;5-Methyl-2-phenyl-2H-pyrazole-3-ol
• CAS NO: 942-32-5
• Molecular Formula: C₁₀H₁₀N₂O
• Molecular Weight: 174.1992
• EINECS: 213-390-4
• Mol File: 942-32-5.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 323.213 °C at 760 mmHg
• Flash Point: 149.274 °C
• Appearance: /
• Density: 1.178 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.606
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-methyl-1-phenyl-1H-pyrazol-5-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-1-phenyl-1H-pyrazol-5-ol(942-32-5)
• EPA Substance Registry System: 3-methyl-1-phenyl-1H-pyrazol-5-ol(942-32-5)

Safety Data

• Hazardous Substances Data: 942-32-5(Hazardous Substances Data)

Usage

General Description

3-methyl-1-phenyl-1H-pyrazol-5-ol is a chemical compound with the molecular formula C10H10N2O. It consists of a pyrazole ring with a phenyl and a methyl group attached at the 1 and 3 positions, respectively. 3-methyl-1-phenyl-1H-pyrazol-5-ol is used in the pharmaceutical industry as a building block for the synthesis of various drugs and dyes. It has also been studied for its potential therapeutic effects, particularly as an anti-inflammatory and analgesic agent. Additionally, it has been investigated for its antioxidant properties and its potential use in the treatment of various diseases. Overall, 3-methyl-1-phenyl-1H-pyrazol-5-ol is a versatile chemical compound with promising applications in the medical and pharmaceutical fields.

InChI:InChI=1/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-7,13H,1H3

Upstream product

• 59-88-1 phenylhydrazine hydrochloride 
• 89-25-8 edaravone 
• 143699-06-3 4,4'-(4-chlorophenylmethylene)-bis-(3-methyl-1-phenyl-1H-pyrazol-5-ol) 
• 96068-42-7 4,4'-[(4-nitrophenyl)methylene]bis(3-methyl-1-phenyl-1H-pyrazol-5-ol) 
• 57303-46-5 4,4'-(phenylmethylene)bis(3-methyl-1-phenyl-pyrazol-5-ol) 
• 87100-61-6 1-(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)butane-1,3-dione 
• 95-54-5 1,2-diamino-benzene 
• 16867-03-1 2-amino-3-hydroxypyridine 
• 2243-55-2 1-(1-naphthyl)hydrazine 
• 141-97-9 ethyl acetoacetate 
• 100-63-0 phenylhydrazine 
• 105-45-3 acetoacetic acid methyl ester 
• 6078-46-2 ethyl 3-(2-phenylhydrazono)butanoate 
• 99068-19-6 C₁₀H₁₂N₂O₂ 

Downstream Products

• 144284-93-5 C₂₇H₂₄N₄O₂*C₄H₉N 
• 23901-60-2 4-benzylidene-3-methyl-1-phenylpyrazolone 
• 25111-95-9 4,4'-benzylidene-bis(1-phenyl-3-methyl-2-pyrazolin-5-one) 
• 39143-08-3 Z-1-phenyl-3-methyl-4-<(4-dimethylaminophenyl)methylene>-5-pyrazolone 
• 132603-49-7 E-1-phenyl-3-methyl-4-<(4-dimethylaminophenyl)methylene>-5-pyrazolone 
• 39143-07-2 4-anisylidene-3-methyl-1-phenylpyrazol-5-one 
• 88689-02-5 5,5'-dimethyl-2,2'-diphenyl-1,2,1',2'-tetrahydro-4,4'-(4-methoxy-phenylmethanediyl)-bis-pyrazol-3-one 
• 68901-70-2 3-methyl-4-(4-nitrobenzylidene)-1-phenyl-1H-pyrazol-5(4H)-one 
• 96068-41-6 4,4'-p-nitrobenzylidene-bis(1-phenyl-3-methyl-2-pyrazolin-5-one) 
• 10389-64-7 5-methyl-4-(2-nitro-benzylidene)-2-phenyl-2,4-dihydro-pyrazol-3-one 
• 102303-79-7 bis<4'-(3'-methyl-1'-phenylpyrazolin-5-one)yl>-2-nitrophenyl-methane 
• 210099-61-9 5-methyl-2-phenyl-4-<(E)-3-phenyl-2-propenoyl>-1,2-dihydro-3H-pyrazol-3-one 

Relevant articles and documents

4-Substituted quinoline derivatives and preparation methods and applications thereof

The present invention provides a 4-substituted quinoline derivative and preparation method and application thereof, in particular, the present invention relates to a compound shown in formula (I), a method for preparing a compound shown in formula (I), an

Design, synthesis and evaluation of dihydrotriazine derivatives-bearing 5-aryloxypyrazole moieties as antibacterial agents

Abstract: In the present investigation, a series of dihydrotriazine derivatives-bearing 5-aryloxypyrazole moieties were synthesized and their structures were confirmed by different spectral tools. The biological evaluation in vitro revealed that some of the target compounds exerted good antibacterial and antifungal activity in comparison with the reference drugs. Among these novel hybrids, compound 10d showed the most potent activity with minimum inhibitory concentration values (MIC) of 0.5?μg/mL against S. aureus 4220, MRSA 3506 and E. coli 1924 strain. The cytotoxic activity of the compounds 6d, 6m, 10d and 10g was assessed in MCF-7 and HeLa cells. Growth kinetics study showed significant inhibition of bacterial growth when treated with different conc. of 10d. In vitro enzyme study implied that compound 10d exerted its antibacterial activity through DHFR inhibition. Moreover, significant inhibition of biofilm formation was observed in bacterial cells treated with MIC conc. of 10d as visualized by SEM micrographs. Graphic abstract: Twenty-nine target compounds were designed, synthesized and evaluated in terms of their antibacterial and antifungal activities.[Figure not available: see fulltext.].

“On-water” one-pot four-component synthesis of novel 1H-furo[2,3-c]pyrazole-4-amine derivatives

A catalyst-free, simple and green protocol has been accomplished for the synthesis of novel 1H-furo[2,3-c]pyrazole-4-amines in a one-pot four-component domino reaction involving hydrazines, ethyl acetoacetate, aromatic amines and phenylglyoxal monohydrate in water. The protocol presented herein describes in situ generated pyrazolone as intermediate reactants with phenylglyoxal monohydrate in a Knoevenagel condensation followed by a Michael addition of amine, intramolecular cyclization, dehydration and the resulting to the title compound. It was observed that in this protocol bis(pyrazole-5-ols) are formed with amines bearing strong electron withdrawing groups under similar reaction conditions instead of the expected products. The reaction merits the use of water as solvent, no additive catalyst, easy workup, easy purification of products by non-chromatography and provides high yield of products with good purity.