942077-76-1

Basic information

• Product Name: 1-(2-N-Boc-AMinoethyl)pyrrolidine
• Synonyms: 1-(2-N-Boc-AMinoethyl)pyrrolidine;tert-butyl 2-(pyrrolidin-1-yl)ethylcarbamate
• CAS NO: 942077-76-1
• Molecular Formula: C₁₁H₂₂N₂O₂
• Molecular Weight: 214.30458
• EINECS: -0
• Mol File: 942077-76-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(2-N-Boc-AMinoethyl)pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-N-Boc-AMinoethyl)pyrrolidine(942077-76-1)
• EPA Substance Registry System: 1-(2-N-Boc-AMinoethyl)pyrrolidine(942077-76-1)

Safety Data

• Hazardous Substances Data: 942077-76-1(Hazardous Substances Data)

Usage

Structure

A derivative of pyrrolidine with an aminoethyl group and a Boc protecting group on the amino moiety

Role in organic synthesis

Building block for the preparation of various biologically active molecules and pharmaceuticals

Application in asymmetric synthesis

Used as a chiral auxiliary due to the presence of a chiral center in its structure

Potential applications

Development of new drugs and research into the treatment of various diseases

Upstream product

• 7154-73-6 1-(2-aminoethyl)pyrrolidine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 40808-62-6 1H(2-pyrrole)β-ethylamine 
• 23159-07-1 3-(1-pyrrolidinyl)propylamine 
• 26690-80-2 2-(N-tert-butoxycarbonylamino)ethanol 
• 123-75-1 pyrrolidine 
• 39684-80-5 2-(tert-butoxycarbonylamino)ethyl bromide 

Downstream Products

• 32776-22-0 1-(2-methylaminoethyl)pyrrolidine 
• 7154-73-6 1-(2-aminoethyl)pyrrolidine 

Relevant articles and documents

Thiazole orange – Spermine conjugate: A potent human telomerase inhibitor comparable to BRACO-19

In this report, we synthesized a series of TO conjugates containing different amino side chains and investigated their binding to telomeric G-quadruplex DNA (G4) using several biophysical methods including fluorometric titration and thermal denaturation monitored by fluorescence and circular dichroism. The composition of side chains strongly affects the binding of these molecules to G-quadruplex DNA. Incorporation of amino side chains increases the binding affinity of TO toward G4 but has a minimal effect on its selectivity for G4 over duplex DNA. The plausible binding modes are a synergistic effect of end-stacking and groove interactions as indicated by docking studies. Inhibition of human telomerase activity by TO derivatives was determined in vitro by the TRAP assay. Several derivatives can selectively inhibit the activity of telomerase over DNA polymerase at low concentrations. More significantly, TO-spermine conjugate (16) exhibits a remarkable effect on telomerase inhibition in the submicromolar range, which is comparable to the inhibition effect of a well-known G4 ligand, BRACO-19. Our results here provide guidance of utilizing TO derivatives as a viable scaffold to design novel G4 ligands, G4 probes, and potent telomerase inhibitors.

Bifunctional phase-transfer catalysts for fixation of CO2 with epoxides under ambient pressure

A series of bifunctional phase-transfer catalysts with a quaternary onium center and a hydrogen-bonding donor group were prepared for the fixation of CO2 with commercially available epoxides under mild conditions by using a CO2 balloon (1 atm). In the presence of 2.5 mol% of achiral bifunctional phase-transfer catalysts, cyclic carbonates were obtained in good to excellent yields (up to 95%). Additionally, optical carbonates and epoxides were obtained through the kinetic resolution of rac-epoxides by 1 mol% of chiral bifunctional phase-transfer catalysts with low enantioselectivities. These catalysts featured a simple synthetic route, good modularity and high efficiency.

FUSED-RING OR TRICYCLIC ARYL PYRIMIDINE COMPOUND USED AS KINASE INHIBITOR

Disclosed is a fused-ring or tricyclic aryl pyrimidine compound used as a mutation selectivity EGFR inhibitor. Specifically, disclosed is a compound represented by formula (I) and used as an EGFR inhibitor or a pharmaceutically acceptable salt thereof.