942144-43-6 Usage
General Description
Tert-butyl (S)-1-hydroxy-3-((S)-tetrahydro-2H-pyran-3-yl)propan-2-ylcarbamate is a chemical compound that is commonly used in the pharmaceutical industry. It is a carbamate derivative that contains a tert-butyl group and a hydroxypropan-2-yl group. The compound has potential medicinal properties and is often used in the synthesis of pharmaceutical drugs. It may also have applications in research and development of new therapeutic agents. The specific stereochemistry of the compound, with both (S)-configurations, is important for its biological activity and potential pharmacological effects. Overall, tert-butyl (S)-1-hydroxy-3-((S)-tetrahydro-2H-pyran-3-yl)propan-2-ylcarbamate is a valuable chemical with potential uses in the pharmaceutical and biotechnology industries.
Check Digit Verification of cas no
The CAS Registry Mumber 942144-43-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,2,1,4 and 4 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 942144-43:
(8*9)+(7*4)+(6*2)+(5*1)+(4*4)+(3*4)+(2*4)+(1*3)=156
156 % 10 = 6
So 942144-43-6 is a valid CAS Registry Number.
942144-43-6Relevant articles and documents
Discovery of VTP-27999, an alkyl amine renin inhibitor with potential for clinical utility
Jia, Lanqi,Simpson, Robert D.,Yuan, Jing,Xu, Zhenrong,Zhao, Wei,Cacatian, Salvacion,Tice, Colin M.,Guo, Joan,Ishchenko, Alexey,Singh, Suresh B.,Wu, Zhongren,McKeever, Brian M.,Bukhtiyarov, Yuri,Johnson, Judith A.,Doe, Christopher P.,Harrison, Richard K.,McGeehan, Gerard M.,Dillard, Lawrence W.,Baldwin, John J.,Claremon, David A.
, p. 747 - 751 (2011/12/01)
Structure guided optimization of a series of nonpeptidic alkyl amine renin inhibitors allowed the rational incorporation of additional polar functionality. Replacement of the cyclohexylmethyl group occupying the S1 pocket with a (R)-(tetrahydropyran-3-yl)
RENIN INHIBITORS AND METHOD OF USE THEREOF
-
, (2010/01/12)
Disclosed are aspartic protease inhibitors represented by the following Formula: wherein R1 , R2, R3, R4, R5, R6, R7a, R7b and n are as defined herein, or a pharmaceut