943126-72-5

Basic information

• Product Name: 2-chloro-1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanone
• Synonyms: 2-chloro-1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanone
• CAS NO: 943126-72-5
• Molecular Formula: C₁₁H₁₀ClFO₂
• Molecular Weight: 229
• EINECS: -0
• Mol File: 943126-72-5.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-chloro-1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanone(943126-72-5)
• EPA Substance Registry System: 2-chloro-1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanone(943126-72-5)

Safety Data

• Hazardous Substances Data: 943126-72-5(Hazardous Substances Data)

Upstream product

• 1017878-51-1 dimethylsulfoxonium-2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-oxoethylide 
• 99199-59-4 6-fluoro-4-oxo-4H-1-benzopyran-2-carboxylic acid 
• 874649-82-8 (-)-(R)-methyl 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylate 
• 74-97-5 chlorobromomethane 
• 394-32-1 1-(5-fluoro-2-hydroxyphenyl)ethan-1-one 
• 99199-61-8 6-fluoro-3,4-dihydro-2H-benzopyran-2-carboxylic acid ethyl ester 
• 593-71-5 Chloroiodomethane 
• 850896-51-4 nebulic acid chloride 
• 99199-60-7 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid 
• 943126-70-3 (+/-)-3-(6-fluorochroman-2-yl)-3-oxo-propionic acid tert-butyl ester 
• 943126-67-8 (+/-)-5-[6-fluorochroman-2-carbonyl]-2, 2-dimethyl[1, 3]dioxane-4, 6-dione 
• 943126-76-9 C₁₂H₁₁FO₄ 

Downstream Products

• 99199-90-3 6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran 
• 99199-91-4 (+/-)-[1S*(R*)]-6-fluoro-3,4-dihydro-α-[[(phenylmethyl)amino]methyl]-2H-1-benzopyran-2-methanol 
• 793669-26-8 [1R*(R*)]-6-fluoro-3,4-dihydro-2-(oxiran-2-yl)-2H-chromene 
• 793669-26-8 [1S*(R*)]-6-fluoro-3,4-dihydro-2-(oxiran-2-yl)-2H-chromene 

Relevant articles and documents

Preparation method of 2-chloro-1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)ethanone

The invention provides a preparation method of 2-chloro-1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)ethanone shown as a formula (I). The preparation method comprises the following steps: step (a), preparing an organic zinc reagent (III): enabling zinc powder and a compound shown as a formula (IV) to react in an anhydrous solvent A for 2 to 3h at 50 to 70 DEG C, so as to generate the organic zincreagent (III), wherein in the formula (III) or (IV), X1 is selected from Cl, Br and I and X2 is Cl; step (b), enabling the organic zinc reagent which does not need to be post-treated, and 6-fluoro-2-cyano-3,4-dihydro-2H-1-benzopyran shown as a formula (II) to react in an anhydrous solvent B for 15 to 48h at 0 to 45 DEG C; then quenching the unreacted organic zinc reagent and treating an obtained reaction solution to obtain the 2-chloro-1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)ethanone shown as the formula (I). The method provided by the invention has the advantages of simple technology, moderate reaction conditions and high safety and is suitable for industrial production. The formula of step (b) is shown in the description.

METHOD FOR PREPARING NEBIVOLOL

The present invention relates to a process for the preparation of nebivolol and, more particularly, to an improved process of synthesizing an alpha-haloketone of formula a key intermediate in the preparation of nebivolol.

Process for preparation of racemic Nebivolol

A process of making racemic [2S*[R*[R*[R*]]]] and [2R*[S*[S*[S*]]]]-(±)α,α′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] of the compound of the formula (I) and its pure [2S*[R*[R*[R*]]]]- and [2R*[S*[S*[S*]]]]-enantiomer compo