99199-91-4

Basic information

• Product Name: 2H-1-Benzopyran-2-methanol, 6-fluoro-3,4-dihydro-a-[[(phenylmethyl)amino]methyl]-
• CAS NO: 99199-91-4
• Molecular Formula: C18H20FNO2
• Molecular Weight: 301.361
• Mol File: 99199-91-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2H-1-Benzopyran-2-methanol, 6-fluoro-3,4-dihydro-a-[[(phenylmethyl)amino]methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1-Benzopyran-2-methanol, 6-fluoro-3,4-dihydro-a-[[(phenylmethyl)amino]methyl]-(99199-91-4)
• EPA Substance Registry System: 2H-1-Benzopyran-2-methanol, 6-fluoro-3,4-dihydro-a-[[(phenylmethyl)amino]methyl]-(99199-91-4)

Safety Data

• Hazardous Substances Data: 99199-91-4(Hazardous Substances Data)

Upstream product

• 99199-90-3 6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran 
• 100-46-9 benzylamine 
• 793669-26-8 [1R*(R*)]-6-fluoro-3,4-dihydro-2-(oxiran-2-yl)-2H-chromene 
• 793669-26-8 [1S*(R*)]-6-fluoro-3,4-dihydro-2-(oxiran-2-yl)-2H-chromene 
• 943126-76-9 C₁₂H₁₁FO₄ 
• 943126-67-8 (+/-)-5-[6-fluorochroman-2-carbonyl]-2, 2-dimethyl[1, 3]dioxane-4, 6-dione 
• 943126-70-3 (+/-)-3-(6-fluorochroman-2-yl)-3-oxo-propionic acid tert-butyl ester 
• 943126-72-5 2-chloro-1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)ethan-1-one 
• 99199-60-7 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid 
• 850896-51-4 nebulic acid chloride 
• 99199-90-3 (+/-)-[1S*(S*)]-6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran 
• 99199-62-9 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol 
• 99199-59-4 6-fluoro-4-oxo-4H-1-benzopyran-2-carboxylic acid 
• 409346-73-2 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxaldehyde 

Downstream Products

• 99200-09-6 nebivolol 
• 929706-85-4 (+/-)-[2R*[1S*,5S*(S*)]]-α,α-[phenylmethyliminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] 
• 929706-85-4 (+/-)-[2R*[1S*,5R*(R*)]]-α,α-[phenylmethyliminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] 
• 929706-85-4 α,α'-[[(phenylmethyl)imino]bismethylene]bis-[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] 

Relevant articles and documents

Process for preparation of racemic Nebivolol

A process of making racemic [2S*[R*[R*[R*]]]] and [2R*[S*[S*[S*]]]]-(±)α,α′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] of the compound of the formula (I) and its pure [2S*[R*[R*[R*]]]]- and [2R*[S*[S*[S*]]]]-enantiomer compo

NEBIVOLOL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS, PROCESS FOR PREPARATION AND PHARMACEUTICAL COMPOSITIONS OF NEBIVOLOL

The present invention provides an improved process for the synthesis of nebivolol or its pharmaceutically acceptable salts, more particularly hydrochloride salt of formula (I). The present invention further provides a new Form T1 of nebivolol and its pharmaceutically acceptable salts. The present invention also provides pharmaceutical compositions and process for the preparation of a solid oral dosage form of nebivolol hydrochloride of formula (I), without the use of wetting agent, and optionally using binder and /or disintegrant.