99200-09-6 Usage
Description
Nebilet was launched in Germany and the Netherlands as an
antihypertensive agent. It is prepared by a five step route starting with 6-fluoro-4-
oxobenzopyran-2-carboxylic acid. It is a selective β1-adrenergic receptor antagonist
and is 50 times less potent at β2-receptors. Vasodialating properties occur via the
nitric oxide pathway. While the L-isomer is more potent than the D-isomer, the
racemic mixture is necessary for optimal activity. Upon administration, an immediate
fall in blood pressure occurs, it improves both left ventricular systolic and diastolic
function, and lowers peripheral blood resistance. Nebilet does not influence insulin
sensitivity nor lipid profile comparible to atenolol. Doses of 50 mg of atenolol and 10
mg of Nebilet are equipotent but Nebilet has a longer duration of action due to an
accumulation of the drug and increasing plasma levels of active metabolites.
Uses
Labeled Nebivolol, intended for use as an internal standard for the quantification of Nebivolol by GC- or LC-mass spectrometry.
Definition
ChEBI: A member of the class of chromanes that is 2,2'-iminodiethanol in which one hydrogen attached to each hydroxy-bearing carbon is replaced by a 6-fluorochroman-2-yl group.
Brand name
Nebilet
Check Digit Verification of cas no
The CAS Registry Mumber 99200-09-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,9,2,0 and 0 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 99200-09:
(7*9)+(6*9)+(5*2)+(4*0)+(3*0)+(2*0)+(1*9)=136
136 % 10 = 6
So 99200-09-6 is a valid CAS Registry Number.
InChI:InChI=1/C22H25F2NO4/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2
99200-09-6Relevant articles and documents
Preparation method and application of Smo inhibitor based on Nebivolol
-
, (2019/10/17)
The invention discloses a preparation method and an application of a Smo inhibitor based on Nebivolol. The structural formula of the Smo inhibitor is as shown in a formula (I). The invention further discloses a synthetic method and an application of the Smo inhibitor. According to the Smo inhibitor, a beta-receptor retardant Nebivolol with inhibitory activity for Smo proteins serves as a lead compound, and optimization reconstruction is implemented based on the beta-receptor retardant Nebivolol to obtain the Smo inhibitor with good inhibitory activity.
PREPARATION OF NEBIVOLOL
-
, (2011/10/19)
Processes for the synthesis of pharmacologically active 2,2-iminobisethanol derivatives, e.g., 2H-1-benzopyran-2 methanol-α,α′-iminobis(methylene)]bis-[6-fluoro-3,4-dihydro-[2R*[R*[R*(S*)]]]], and their pharmaceutically acceptable salts.
PROCESS FOR PREPARING NEBIVOLOL
-
Page/Page column 11-12, (2010/05/14)
The present invention relates to a process for preparing Nebivolol and, more particularly, to an improved method of debenzylation of a compound of formula (II) useful for preparing nebivolol endowed with high purity.
