944-78-5

Basic information

• Product Name: 1,2,4,5-tetrachloro-3,6-dimethoxybenzene
• Synonyms: 1,2,4,5-tetrachloro-3,6-dimethoxybenzene;1,4-Dimethoxy-2,3,5,6-tetrachlorobenzene;Drosophilin A methyl ether;Tetrachlorohydroquinone dimethyl ether;Benzene,1,2,4,5-tetrachloro-3,6-diMethoxy-;1,2,4,5 tetrachloro-3,6-diMethyoxybenzene
• CAS NO: 944-78-5
• Molecular Formula: C₈H₆Cl₄O₂
• Molecular Weight: 275.95
• Mol File: 944-78-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 165 °C
• Boiling Point: 330.1°Cat760mmHg
• Flash Point: 128.4°C
• Appearance: /
• Density: 1.489g/cm³
• Vapor Pressure: 0.000326mmHg at 25°C
• Refractive Index: 1.552
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1,2,4,5-tetrachloro-3,6-dimethoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4,5-tetrachloro-3,6-dimethoxybenzene(944-78-5)
• EPA Substance Registry System: 1,2,4,5-tetrachloro-3,6-dimethoxybenzene(944-78-5)

Safety Data

• Hazardous Substances Data: 944-78-5(Hazardous Substances Data)

Usage

General Description

1,2,4,5-tetrachloro-3,6-dimethoxybenzene is a chemical compound with the molecular formula C8H6Cl4O2. It is a derivative of benzene and consists of four chlorine atoms and two methoxy groups attached to the benzene ring. 1,2,4,5-tetrachloro-3,6-dimethoxybenzene is commonly used in the synthesis of various organic compounds and as a building block in the development of new materials. It is also known for its potential use as a pesticide and as an intermediate in the production of pharmaceuticals. However, it is important to handle this compound with caution as it is considered to be hazardous to health and the environment.

InChI:InChI=1/C8H6Cl4O2/c1-13-7-3(9)5(11)8(14-2)6(12)4(7)10/h1-2H3

Upstream product

• 186581-53-3 diazomethane 
• 87-87-6 2,3,5,6-tetrachlorobenzene-1,4-diol 
• 3117-03-1 2,5-dimethoxyquinone 
• 75-36-5 acetyl chloride 
• 150-78-7 1,4-dimethoxybezene 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 
• 118-75-2 chloranil 
• 138723-90-7 2,5-dihydro-2,2-dimethoxy-5,5-dimethyl-1,3,4-oxadiazole 
• 7446-70-0 aluminium trichloride 

Downstream Products

• 1063744-80-8 3,4,6-trichloro-2,5-dimethoxy-biphenyl 
• 69653-71-0 2,3,5-trichloro-1,4-dimethoxybenzene 
• 118-75-2 chloranil 

Relevant articles and documents

Chlorination increases the persistence of semiquinone free radicals derived from polychlorinated biphenyl hydroquinones and quinones

(Chemical Equation Presented) Polychlorinated biphenyls (PCBs) comprise a group of persistent organic pollutants that differ significantly in their physicochemical properties, their persistence, and their biological activities. They can be metabolized via

Oxidative Dealkylation of Hydroquinone Ethers with Nitrogen Dioxide in the Convenient Preparation of Quinones

Various Hydroquinone dialkyl ethers (R2Q) are effectively converted by nitrogen dioxide into the corresponding quinone (Q) and alkyl nitrite (RONO) in dichloromethane at room temperature or below.The preparative procedure for the isolation of crystalline quinones in quantitative yield merely involves the convenient removal of the low boiling solvent in vacuo.Isotopic labelling studies demonstrate that the oxidative dealkylation proceeds via alkoxy scission of the labile cation radical (R2Q-cation radical) formed via the oxidation of the hydroquinone ether by nitrogen dioxide ( as the disproportionated ion pair NO+NO3-).The electron-transfer mechanism is confirmed by the spectral observation of R2Q-cation radical (identified by the isolation of the crystalline salt R2Q-cation radical-SbCl6-) and its rapid conversion into quinone and alkyl nitrite by combination with nitrate (NO3-) and nitric oxide (NO).

Facile Synthesis of Chloro-substituted Aromatic Ethers by Use of Benzyltrimethylammonium Tetrachloroiodate

The reaction of aromatic ethers with a calculated amount of benzyltrimethylammonium tetrachloroiodate in acetic acid (or dichloromethane) under mild conditions gave, selectively, the objective chloro-substituted aromatic ethers in good yields.